Oxazolo[4,5-b]pyridine, 2-methyl-, 4-oxide (9CI)

Base Information

• Chemical Name: Oxazolo[4,5-b]pyridine, 2-methyl-, 4-oxide (9CI)
• CAS No.: 114658-11-6
• Molecular Formula: C₇H₆N₂O₂
• Molecular Weight: 150.137
• Mol file: 114658-11-6.mol

Synonyms:Oxazolo[4,5-b]pyridine, 2-methyl-, 4-oxide (9CI)

Chemical Property of Oxazolo[4,5-b]pyridine, 2-methyl-, 4-oxide (9CI)

Chemical Property:

• PSA: 51.49000
• LogP: 1.56470

Purity/Quality:

2-methyl-Oxazolo[4,5-b]pyridine4-oxide 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Oxazolo[4,5-b]pyridine, 2-methyl-, 4-oxide (9CI)

There total 3 articles about Oxazolo[4,5-b]pyridine, 2-methyl-, 4-oxide (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

2-acetyl-3-hydroxypyridine 1-oxide (114658-10-5) → 2-methyloxazolo<4,5-b>pyridine 4-oxide (114658-11-6) + 2-acetylamino-3-hydroxypyridine 1-oxide (114658-12-7)

Guidance literature:

With sodium hydrogencarbonate; hydroxylamine-O-sulfonic acid; In diethyl ether; water; for 5h; Ambient temperature;

Reference yield:

1-(3-hydroxypyridin-2-yl)ethan-1-one (13210-29-2) → 2-methyloxazolo<4,5-b>pyridine 4-oxide (114658-11-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / pyridine / 3 h / 60 - 70 °C

2: 67 percent / MCPBA / CHCl₃ / 36 h / Ambient temperature

3: 46 percent / H₂NOSO₃H, NaHCO₃ / diethyl ether; H₂O / 5 h / Ambient temperature

With pyridine; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; hydroxylamine-O-sulfonic acid; In diethyl ether; chloroform; water;

Reference yield:

2-acetyl-3-acetoxypyridine (114658-09-2) → 2-methyloxazolo<4,5-b>pyridine 4-oxide (114658-11-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / MCPBA / CHCl₃ / 36 h / Ambient temperature

2: 46 percent / H₂NOSO₃H, NaHCO₃ / diethyl ether; H₂O / 5 h / Ambient temperature

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; hydroxylamine-O-sulfonic acid; In diethyl ether; chloroform; water;

upstream raw materials:

2-acetyl-3-hydroxypyridine 1-oxide

1-(3-hydroxypyridin-2-yl)ethan-1-one

2-acetyl-3-acetoxypyridine

Downstream raw materials:

2-methyloxazolo<4,5-b>pyridine