N'-(4-chlorophenyl)-N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine

Base Information

Chemical Name:N'-(4-chlorophenyl)-N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine
CAS No.:1051897-31-4
Molecular Formula:C₂₅H₂₉ClN₆O₂
Molecular Weight:480.997
Hs Code.:

Synonyms:N'-(4-chlorophenyl)-N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N'-(4-chlorophenyl)-N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine

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Technology Process of N'-(4-chlorophenyl)-N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine

There total 6 articles about N'-(4-chlorophenyl)-N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 106-39-8
bromochlorobenzene

: 1051899-45-6
N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine

: 1051897-31-4
N'-(4-chlorophenyl)-N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine

Guidance literature:: With potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 120 ℃; for 20h;

Reference yield:

: 945397-01-3
4-chloro-N-(3,5-dimorpholin-4-ylphenyl)pyrimidin-2-amine

: 1051897-31-4
N'-(4-chlorophenyl)-N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 20 h / 140 °C

2: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 20 h / 120 °C

With potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In methanol; toluene;

Reference yield:

: 945397-00-2
N-(3,5-dimorpholin-4-ylphenyl)formamide

: 1051897-31-4
N'-(4-chlorophenyl)-N-(3,5-dimorpholin-4-ylphenyl)-N'-methyl-pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 - 20 °C

1.2: 0 - 20 °C

1.3: 1 h

2.1: methanol / 20 h / 140 °C

3.1: potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 20 h / 120 °C

With sodium hydride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tetrahydrofuran; methanol; toluene;