Fmoc-Gly-ODhbt

Base Information

• Chemical Name: Fmoc-Gly-ODhbt
• CAS No.: 114119-87-8
• Molecular Formula: C24H18 N4 O5
• Molecular Weight: 442.431
• Mol file: 114119-87-8.mol

Synonyms:1,2,3-Benzotriazine,carbamic acid deriv.

Chemical Property of Fmoc-Gly-ODhbt

Chemical Property:

• PSA: 112.41000
• LogP: 2.67630

Purity/Quality:

98.5% ^*data from raw suppliers

Fmoc-Gly-ODHBt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Fmoc-Gly-ODHBt is used as a reactant in the synthesis of solid-phase glycopeptides.

Technology Process of Fmoc-Gly-ODhbt

There total 1 articles about Fmoc-Gly-ODhbt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + 3-hydroxy-3,4-dihydrobenzotriazine-4-one (28230-32-2) → Fmoc-Gly-ODhbt (114119-87-8)

Guidance literature:

With thionyl chloride; In dichloromethane; Heating;

DOI:10.1016/0040-4039(91)80788-8

Reference yield:

(O-tert-butyl)-L-threonine (4378-13-6,201353-89-1) + Fmoc-Ser(tBu)-ODhbt (109434-27-7,201210-27-7) + Fmoc-Gly-ODhbt (114119-87-8) + Nα-(fluoren-9-ylmethoxycarbonyl)-3-O-<2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1<*>3)-4,6-di-O-acetyl-2-azido-2-deoxy-D-galactopyranosyl>-L-threonine pentafluorophenyl ester → C60H94N10O30

Guidance literature:

Multistep reaction;

DOI:10.1016/0008-6215(94)00292-N

Reference yield:

(O-tert-butyl)-L-threonine (4378-13-6,201353-89-1) + Fmoc-Ser(tBu)-ODhbt (109434-27-7,201210-27-7) + Fmoc-Gly-ODhbt (114119-87-8) + Nα-(fluoren-9-ylmethoxycarbonyl)-3-O-<2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1<*>3)-4,6-di-O-acetyl-2-azido-2-deoxy-D-galactopyranosyl>-L-threonine pentafluorophenyl ester → C60H94N10O30

Guidance literature:

Multistep reaction;

DOI:10.1016/0008-6215(94)00292-N

upstream raw materials:

N-(fluoren-9-ylmethoxycarbonyl)glycine

3-hydroxy-3,4-dihydrobenzotriazine-4-one