8a-bromo-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide

Base Information

• Chemical Name: 8a-bromo-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide
• CAS No.: 86268-19-1
• Molecular Formula: C₁₇H₁₆BrO₂P
• Molecular Weight: 363.191
• Mol file: 86268-19-1.mol

Synonyms:8a-bromo-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide

Chemical Property of 8a-bromo-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8a-bromo-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide

There total 4 articles about 8a-bromo-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-phenyl-2,3-dihydro-8H,λ5-indeno[2,1-b]phosphol-1-one (86268-16-8) → 8a-bromo-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide (86268-19-1)

Guidance literature:

With N-Bromosuccinimide; In tetrahydrofuran; water; for 22h;

DOI:10.1016/S0040-4020(01)88540-9

Reference yield:

3-vinyl-1H-indene (63927-06-0) → 8a-bromo-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide (86268-19-1)

Guidance literature:

Multi-step reaction with 3 steps

1: copper stearate / hexane / 192 h / Ambient temperature

2: satd. aq. NaHCO₃ / H₂O

3: 60 percent / N-bromosuccinimide / tetrahydrofuran; H₂O / 22 h

With N-Bromosuccinimide; copper octadecanoate; sodium hydrogencarbonate; In tetrahydrofuran; hexane; water;

DOI:10.1016/S0040-4020(01)88540-9

Reference yield:

1-vinyl-1-indanol (6221-21-2) → 8a-bromo-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide (86268-19-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / iodine, quinoline / benzene / Heating

2: copper stearate / hexane / 192 h / Ambient temperature

3: satd. aq. NaHCO₃ / H₂O

4: 60 percent / N-bromosuccinimide / tetrahydrofuran; H₂O / 22 h

With quinoline; N-Bromosuccinimide; copper octadecanoate; iodine; sodium hydrogencarbonate; In tetrahydrofuran; hexane; water; benzene;

DOI:10.1016/S0040-4020(01)88540-9

upstream raw materials:

1-phenyl-2,3-dihydro-8H,λ⁵-indeno[2,1-b]phosphol-1-one

3-vinyl-1H-indene

1-vinyl-1-indanol

1-Bromo-1-phenyl-1,2,3,8-tetrahydro-indeno[2,1-b]phospholium; bromide

Downstream raw materials:

1-phenyl-2,3-dihydro-8H-indeno[2,1-b]phosphole

1,2,3,3a-tetrahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide

8-ethoxy-1,2,3,3a,8,8a-hexahydro-3a-hydroxy-1-phenylindeno<2,1-b>phosphole 1-oxide

1-phenyl-2,3-dihydro-8H,λ⁵-indeno[2,1-b]phosphol-1-one