base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine]

Base Information

Chemical Name:base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine]
CAS No.:72364-78-4
Molecular Formula:C₁₈H₁₇Cl₂NS
Molecular Weight:350.312
Hs Code.:

Synonyms:base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine]

Suppliers and Price of base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine]

Chemical Property:

Purity/Quality:

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Technology Process of base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine]

There total 6 articles about base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 72364-76-2
3-(2,4-dichlorophenyl)-1,3-dihydro-1'-phenoxycarbonylspiro[benzo(c)thiophene-1,4'-piperidine]

: 72364-78-4
base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: With potassium hydroxide; In ethylene glycol; at 155 ℃; for 0.5h;
DOI:10.1021/jm00133a016

Reference yield:

: 1445-73-4
1-Methyl-4-piperidone

: 72364-78-4
base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -60 deg C to RT

2: BF₃, glacial AcOH / 15 h / 60 °C

3: dimsyl sodium / dimethylsulfoxide / 1 h / Ambient temperature

4: 77 percent / NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

5: 85percent KOH / ethane-1,2-diol / 0.5 h / 155 °C

With potassium hydroxide; n-butyllithium; boron trifluoride; sodium hydrogencarbonate; sodium methylsulfinylmethanide; acetic acid; In dichloromethane; ethylene glycol; dimethyl sulfoxide;
DOI:10.1021/jm00133a016

Reference yield:

: 1072-85-1
o-fluorobromobenzene

: 72364-78-4
base 3-(2,4-dichlorophenyl)-1,3-dihydrospiro[benzo(c)thiophene-1,4'-piperidine]

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi / 1.) THF, -70 deg C, 1 h, 2.) THF, from -60 deg C to RT

2: BF₃, glacial AcOH / 15 h / 60 °C

3: dimsyl sodium / dimethylsulfoxide / 1 h / Ambient temperature

4: 77 percent / NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

5: 85percent KOH / ethane-1,2-diol / 0.5 h / 155 °C

With potassium hydroxide; n-butyllithium; boron trifluoride; sodium hydrogencarbonate; sodium methylsulfinylmethanide; acetic acid; In dichloromethane; ethylene glycol; dimethyl sulfoxide;
DOI:10.1021/jm00133a016