methyl 2-[3-(cyclohexylamino)-2-(2-nitrophenyl)imidazo[1,2-a]pyridin-8-yl]-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

Base Information

Chemical Name:methyl 2-[3-(cyclohexylamino)-2-(2-nitrophenyl)imidazo[1,2-a]pyridin-8-yl]-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate
CAS No.:1430101-52-2
Molecular Formula:C₃₂H₃₄N₆O₅
Molecular Weight:582.659
Hs Code.:

Synonyms:methyl 2-[3-(cyclohexylamino)-2-(2-nitrophenyl)imidazo[1,2-a]pyridin-8-yl]-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

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Chemical Property of methyl 2-[3-(cyclohexylamino)-2-(2-nitrophenyl)imidazo[1,2-a]pyridin-8-yl]-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

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Technology Process of methyl 2-[3-(cyclohexylamino)-2-(2-nitrophenyl)imidazo[1,2-a]pyridin-8-yl]-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

There total 6 articles about methyl 2-[3-(cyclohexylamino)-2-(2-nitrophenyl)imidazo[1,2-a]pyridin-8-yl]-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 931-53-3
Cyclohexyl isocyanide

: 1430101-82-8
methyl 2-(2-amino-3-pyridyl)-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

: 552-89-6
2-nitro-benzaldehyde

: 1430101-52-2
methyl 2-[3-(cyclohexylamino)-2-(2-nitrophenyl)imidazo[1,2-a]pyridin-8-yl]-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

Guidance literature:: With scandium tris(trifluoromethanesulfonate); In neat (no solvent); at 135 ℃; Microwave irradiation; Inert atmosphere; Green chemistry;
DOI:10.1021/co400010y

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1430101-52-2
methyl 2-[3-(cyclohexylamino)-2-(2-nitrophenyl)imidazo[1,2-a]pyridin-8-yl]-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 0.17 h / 80 °C / Microwave irradiation; Inert atmosphere

2: zinc; ammonium formate / methanol / 0.08 h / 90 °C / Microwave irradiation; Inert atmosphere

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation; Inert atmosphere

4: trifluoroacetic acid; magnesium sulfate / 1,2-dichloro-ethane / 0.17 h / 130 °C / Microwave irradiation; Inert atmosphere

5: scandium tris(trifluoromethanesulfonate) / neat (no solvent) / 135 °C / Microwave irradiation; Inert atmosphere; Green chemistry

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; magnesium sulfate; triethylamine; trifluoroacetic acid; scandium tris(trifluoromethanesulfonate); zinc; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/co400010y

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1430101-52-2
methyl 2-[3-(cyclohexylamino)-2-(2-nitrophenyl)imidazo[1,2-a]pyridin-8-yl]-1-(3-methoxypropyl)-1H-benzo[d]imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 0.25 h / 80 °C / Microwave irradiation; Inert atmosphere

2: dichloromethane / 0.17 h / 80 °C / Microwave irradiation; Inert atmosphere

3: zinc; ammonium formate / methanol / 0.08 h / 90 °C / Microwave irradiation; Inert atmosphere

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / N,N-dimethyl-formamide / 0.17 h / 160 °C / Microwave irradiation; Inert atmosphere

5: trifluoroacetic acid; magnesium sulfate / 1,2-dichloro-ethane / 0.17 h / 130 °C / Microwave irradiation; Inert atmosphere

6: scandium tris(trifluoromethanesulfonate) / neat (no solvent) / 135 °C / Microwave irradiation; Inert atmosphere; Green chemistry

With sulfuric acid; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; magnesium sulfate; triethylamine; trifluoroacetic acid; scandium tris(trifluoromethanesulfonate); zinc; In methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/co400010y