(S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2,5,6-trimethoxybenzamide

Base Information

• Chemical Name: (S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2,5,6-trimethoxybenzamide
• CAS No.: 101460-23-5
• Molecular Formula: C₁₇H₂₅ClN₂O₄
• Molecular Weight: 356.849
• Mol file: 101460-23-5.mol

Synonyms:(S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2,5,6-trimethoxybenzamide

Chemical Property of (S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2,5,6-trimethoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2,5,6-trimethoxybenzamide

There total 4 articles about (S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2,5,6-trimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-(-)-2-aminoethyl-1-ethylpyrrolidine (1315056-31-5) + iPr2 O + 3-chloro-2,5,6-trimethoxybenzoic acid (101460-24-6) → (S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2,5,6-trimethoxybenzamide (101460-23-5)

Guidance literature:

With thionyl chloride; In chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

1,2,4-trimethoxy-benzene (135-77-3) → (S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2,5,6-trimethoxybenzamide (101460-23-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, 20 deg C, 2.) Et₂O

2: 100 percent / SO₂Cl₂ / CHCl₃ / 2 h / 0 °C

3: thionyl chloride, DMF / toluene / 1 h / 60 °C

4: CHCl₃ / 0.5 h / 50 °C

With n-butyllithium; thionyl chloride; sulfuryl dichloride; N,N-dimethyl-formamide; In chloroform; toluene;

DOI:10.1021/jm00166a012

Reference yield:

2,3,6-trimethoxybenzoic acid (60241-74-9) → (S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2,5,6-trimethoxybenzamide (101460-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / SO₂Cl₂ / CHCl₃ / 2 h / 0 °C

2: thionyl chloride, DMF / toluene / 1 h / 60 °C

3: CHCl₃ / 0.5 h / 50 °C

With thionyl chloride; sulfuryl dichloride; N,N-dimethyl-formamide; In chloroform; toluene;

DOI:10.1021/jm00166a012

upstream raw materials:

1,2,4-trimethoxy-benzene

2,3,6-trimethoxybenzoic acid

3-chloro-2,5,6-trimethoxybenzoic acid

(S)-(-)-2-aminoethyl-1-ethylpyrrolidine

Downstream raw materials:

3-Chloro-N-((S)-1-ethyl-pyrrolidin-2-ylmethyl)-6-hydroxy-2,5-dimethoxy-benzamide

(S)-(-)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-3-chloro-2-hydroxy-5,6-dimethoxybenzamide