N-<2-(2-ethoxyethoxy)ethyl>-5-<<4,5-bis<4-(methylthio)phenyl>-1H-imidazol-2-yl>thio>pentanamide

Base Information

Chemical Name:N-<2-(2-ethoxyethoxy)ethyl>-5-<<4,5-bis<4-(methylthio)phenyl>-1H-imidazol-2-yl>thio>pentanamide
CAS No.:162933-13-3
Molecular Formula:C₂₈H₃₇N₃O₃S₃
Molecular Weight:559.818
Hs Code.:

Synonyms:N-<2-(2-ethoxyethoxy)ethyl>-5-<<4,5-bis<4-(methylthio)phenyl>-1H-imidazol-2-yl>thio>pentanamide

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Chemical Property of N-<2-(2-ethoxyethoxy)ethyl>-5-<<4,5-bis<4-(methylthio)phenyl>-1H-imidazol-2-yl>thio>pentanamide

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Technology Process of N-<2-(2-ethoxyethoxy)ethyl>-5-<<4,5-bis<4-(methylthio)phenyl>-1H-imidazol-2-yl>thio>pentanamide

There total 5 articles about N-<2-(2-ethoxyethoxy)ethyl>-5-<<4,5-bis<4-(methylthio)phenyl>-1H-imidazol-2-yl>thio>pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1026538-44-2
N-<2-(2-ethoxyethoxy)ethyl>-5-bromopentanamide

: 66659-98-1
4,5-bis<4-(methylthio)phenyl>-1H-imidazole-2-thiol

: 162933-13-3
N-<2-(2-ethoxyethoxy)ethyl>-5-<<4,5-bis<4-(methylthio)phenyl>-1H-imidazol-2-yl>thio>pentanamide

Guidance literature:: With potassium carbonate; sodium iodide; In tetrahydrofuran; for 16h; Heating;
DOI:10.1021/jm00007a004

Reference yield:

: 23702-88-7
2-(2-ethoxyethoxy)ethanamine

: 162933-13-3
N-<2-(2-ethoxyethoxy)ethyl>-5-<<4,5-bis<4-(methylthio)phenyl>-1H-imidazol-2-yl>thio>pentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature; 1.) THF,water, RT, 2 h, 2.) THF, water, RT, 4 h

2: 66 percent / K₂CO₃, NaI / tetrahydrofuran / 16 h / Heating

With potassium carbonate; sodium iodide; In tetrahydrofuran;
DOI:10.1021/jm00007a004

Reference yield:

: 54550-36-6
1-bromo-2-(2-ethoxyethoxy)ethane

: 162933-13-3
N-<2-(2-ethoxyethoxy)ethyl>-5-<<4,5-bis<4-(methylthio)phenyl>-1H-imidazol-2-yl>thio>pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide, NaI / dimethylformamide / 18 h / 60 °C

2: 1.) Ph₃P, 2.) H₂O / 1.) THF, RT, 10 h, 2.) THF, RT, 24 h

3: aq. K₂CO₃ / tetrahydrofuran / 4 h / Ambient temperature; 1.) THF,water, RT, 2 h, 2.) THF, water, RT, 4 h

4: 66 percent / K₂CO₃, NaI / tetrahydrofuran / 16 h / Heating

With sodium azide; water; potassium carbonate; triphenylphosphine; sodium iodide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00007a004