Boc-L-Dmt-L-Tic-CH₂N₃

Base Information

Chemical Name:Boc-L-Dmt-L-Tic-CH₂N₃
CAS No.:357339-44-7
Molecular Formula:C₂₆H₃₃N₅O₄
Molecular Weight:479.579
Hs Code.:

Boc-L-Dmt-L-Tic-CH<sub>2</sub>N<sub>3</sub>

Synonyms:Boc-L-Dmt-L-Tic-CH₂N₃

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Chemical Property of Boc-L-Dmt-L-Tic-CH₂N₃

Chemical Property:

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Technology Process of Boc-L-Dmt-L-Tic-CH₂N₃

There total 5 articles about Boc-L-Dmt-L-Tic-CH₂N₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99953-00-1,111633-04-6
(S)-N-Boc-2,6-dimethyltyrosine

: (S)-3-azidomethyl-1,2,3,4-tetrahydro-isoquinoline

: 357339-44-7
Boc-L-Dmt-L-Tic-CH₂N₃

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm015532k

Reference yield:

: 115962-35-1,144069-68-1,78879-20-6
(3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid

: 357339-44-7
Boc-L-Dmt-L-Tic-CH₂N₃

Guidance literature:: Multi-step reaction with 5 steps

1: 4-methyl morpholine / 1,2-dimethoxy-ethane / 0.08 h / 0 °C

2: 1.47 g / NaBH₄ / H₂O / 0.33 h / 0 - 20 °C

3: 86 percent / triphenylphosphine; diethylazodicarboxylate; diphenylphosphonic azide / tetrahydrofuran / 5.5 h / 20 °C

4: aq. HCl; AcOH / 20 °C

5: 55 mg / 1,3-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; DIPEA / dimethylformamide / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; diphenyl phosphoryl azide; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 3: Mitsunobu reaction;
DOI:10.1021/jm015532k

Reference yield:

: 3-isobutoxycarbonyloxycarbonyl-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

: 357339-44-7
Boc-L-Dmt-L-Tic-CH₂N₃

Guidance literature:: Multi-step reaction with 4 steps

1: 1.47 g / NaBH₄ / H₂O / 0.33 h / 0 - 20 °C

2: 86 percent / triphenylphosphine; diethylazodicarboxylate; diphenylphosphonic azide / tetrahydrofuran / 5.5 h / 20 °C

3: aq. HCl; AcOH / 20 °C

4: 55 mg / 1,3-dicyclohexylcarbodiimide; 1-hydroxybenzotriazole; DIPEA / dimethylformamide / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; diphenyl phosphoryl azide; benzotriazol-1-ol; acetic acid; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jm015532k