(4aS,7R,8S,8aS)-7-(hydroxymethyl)-8-phenyloctahydro-3H-2-benzopyran-3-one

Base Information

Chemical Name:(4aS,7R,8S,8aS)-7-(hydroxymethyl)-8-phenyloctahydro-3H-2-benzopyran-3-one
CAS No.:1326231-65-5
Molecular Formula:C₁₆H₂₀O₃
Molecular Weight:260.333
Hs Code.:

Synonyms:(4aS,7R,8S,8aS)-7-(hydroxymethyl)-8-phenyloctahydro-3H-2-benzopyran-3-one

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Chemical Property of (4aS,7R,8S,8aS)-7-(hydroxymethyl)-8-phenyloctahydro-3H-2-benzopyran-3-one

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Technology Process of (4aS,7R,8S,8aS)-7-(hydroxymethyl)-8-phenyloctahydro-3H-2-benzopyran-3-one

There total 5 articles about (4aS,7R,8S,8aS)-7-(hydroxymethyl)-8-phenyloctahydro-3H-2-benzopyran-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: C₁₆H₂₂O₃

: 1326231-65-5
(4aS,7R,8S,8aS)-7-(hydroxymethyl)-8-phenyloctahydro-3H-2-benzopyran-3-one

Guidance literature:: With silver carbonate; In toluene; for 4h; Inert atmosphere; Reflux;
DOI:10.1055/s-0030-1260469

Reference yield: 63.0%

: 1326231-53-1
ethyl [(1S,2S,3S,4R)-2,4-diformyl-3-phenylcyclohexyl]acetate

: 1326231-65-5
(4aS,7R,8S,8aS)-7-(hydroxymethyl)-8-phenyloctahydro-3H-2-benzopyran-3-one

: C₁₆H₂₂O₃

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 ℃; for 6h; Inert atmosphere;
DOI:10.1055/s-0030-1260469

Reference yield:

: 67081-18-9
ethyl (E)-7-oxohept-2-enoate

: 1326231-65-5
(4aS,7R,8S,8aS)-7-(hydroxymethyl)-8-phenyloctahydro-3H-2-benzopyran-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; acetic acid / acetonitrile / 14 h / 20 °C / Inert atmosphere

2: sodium tetrahydroborate / ethanol / 6 h / 0 °C / Inert atmosphere

With (2S)-2-{diphenyl[(trimethylsilyl)oxy]methyl}pyrrolidine; sodium tetrahydroborate; acetic acid; In ethanol; acetonitrile; 1: double Michael reaction;
DOI:10.1055/s-0030-1260469