N-methyl-3-(1H-purin-6-ylamino)-4-{[2-(1-pyrrolidinyl)ethyl]oxy}benzenesuIfonamide

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Chemical Name:N-methyl-3-(1H-purin-6-ylamino)-4-{[2-(1-pyrrolidinyl)ethyl]oxy}benzenesuIfonamide
CAS No.:1351088-31-7
Molecular Formula:C₁₈H₂₃N₇O₃S
Molecular Weight:417.492
Hs Code.:

Synonyms:N-methyl-3-(1H-purin-6-ylamino)-4-{[2-(1-pyrrolidinyl)ethyl]oxy}benzenesuIfonamide

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Chemical Property of N-methyl-3-(1H-purin-6-ylamino)-4-{[2-(1-pyrrolidinyl)ethyl]oxy}benzenesuIfonamide

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Technology Process of N-methyl-3-(1H-purin-6-ylamino)-4-{[2-(1-pyrrolidinyl)ethyl]oxy}benzenesuIfonamide

There total 5 articles about N-methyl-3-(1H-purin-6-ylamino)-4-{[2-(1-pyrrolidinyl)ethyl]oxy}benzenesuIfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 2955-88-6
1-pyrrolidineethanol

: 1351087-88-1
4-fluoro-N-methyl-3-(9H-purin-6-ylamino)benzenesulfonamide

: 1351088-31-7
N-methyl-3-(1H-purin-6-ylamino)-4-{[2-(1-pyrrolidinyl)ethyl]oxy}benzenesuIfonamide

Guidance literature:: 1-pyrrolidineethanol; With sodium hydride; In mineral oil; at 20 ℃; for 0.5h; Microwave irradiation;

4-fluoro-N-methyl-3-(9H-purin-6-ylamino)benzenesulfonamide; In 1-methyl-pyrrolidin-2-one; mineral oil; at 110 ℃; for 20h; Microwave irradiation; Sealed tube;

Reference yield:

: 1493-27-2,127723-77-7
ortho-nitrofluorobenzene

: 1351088-31-7
N-methyl-3-(1H-purin-6-ylamino)-4-{[2-(1-pyrrolidinyl)ethyl]oxy}benzenesuIfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: chlorosulfonic acid / 18 h / 100 °C

2.1: triethylamine / tetrahydrofuran / 1 h / -35 °C

3.1: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

4.1: silver trifluoromethanesulfonate / N,N-dimethyl-formamide / 20 h / 80 °C / Microwave irradiation; Sealed tube

5.1: sodium hydride / mineral oil / 0.5 h / 20 °C / Microwave irradiation

5.2: 20 h / 110 °C / Microwave irradiation; Sealed tube

With chlorosulfonic acid; hydrogen; silver trifluoromethanesulfonate; sodium hydride; triethylamine; palladium; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 6668-56-0
4-fluoro-3-nitrobenzene-1-sulfonyl chloride

: 1351088-31-7
N-methyl-3-(1H-purin-6-ylamino)-4-{[2-(1-pyrrolidinyl)ethyl]oxy}benzenesuIfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / tetrahydrofuran / 1 h / -35 °C

2.1: hydrogen / palladium / tetrahydrofuran / 50 °C / Inert atmosphere

3.1: silver trifluoromethanesulfonate / N,N-dimethyl-formamide / 20 h / 80 °C / Microwave irradiation; Sealed tube

4.1: sodium hydride / mineral oil / 0.5 h / 20 °C / Microwave irradiation

4.2: 20 h / 110 °C / Microwave irradiation; Sealed tube

With hydrogen; silver trifluoromethanesulfonate; sodium hydride; triethylamine; palladium; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;