(2R)-2-{(2S,4S)-2-[(1S)-(bromo)(trimethylsilyl)methyl]-4-isopropylazetidin-1-yl}-2-phenylethanol

Base Information

• Chemical Name: (2R)-2-{(2S,4S)-2-[(1S)-(bromo)(trimethylsilyl)methyl]-4-isopropylazetidin-1-yl}-2-phenylethanol
• CAS No.: 870814-83-8
• Molecular Formula: C₁₈H₃₀BrNOSi
• Molecular Weight: 384.432

Synonyms:(2R)-2-{(2S,4S)-2-[(1S)-(bromo)(trimethylsilyl)methyl]-4-isopropylazetidin-1-yl}-2-phenylethanol

Chemical Property of (2R)-2-{(2S,4S)-2-[(1S)-(bromo)(trimethylsilyl)methyl]-4-isopropylazetidin-1-yl}-2-phenylethanol

Chemical Property:

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Technology Process of (2R)-2-{(2S,4S)-2-[(1S)-(bromo)(trimethylsilyl)methyl]-4-isopropylazetidin-1-yl}-2-phenylethanol

There total 1 articles about (2R)-2-{(2S,4S)-2-[(1S)-(bromo)(trimethylsilyl)methyl]-4-isopropylazetidin-1-yl}-2-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

(R)-2-((E)-(R)-1-Isopropyl-4-trimethylsilanyl-but-3-enylamino)-2-phenyl-ethanol → (2R)-2-{(2S,4S)-2-[(1S)-(bromo)(trimethylsilyl)methyl]-4-isopropylazetidin-1-yl}-2-phenylethanol (870814-83-8)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 0 ℃; for 0.25h;

DOI:10.1002/ejoc.200700283

Reference yield: 94.0%

(2R)-2-{(2S,4S)-2-[(1S)-(bromo)(trimethylsilyl)methyl]-4-isopropylazetidin-1-yl}-2-phenylethanol (870814-83-8) → (2R)-2-{[(1R,3Z)-4-bromo-1-isopropylbut-3-en-1-yl]amino}-2-phenylethanol

Guidance literature:

With hydrogen fluoride; In pyridine;

DOI:10.1016/j.tetlet.2005.09.061

Reference yield: 55.0%

(2R)-2-{(2S,4S)-2-[(1S)-(bromo)(trimethylsilyl)methyl]-4-isopropylazetidin-1-yl}-2-phenylethanol (870814-83-8) → (2R,6S,8R)-8-isopropyl-2-phenyl-4-oxa-1-azabicyclo[4.2.0]octane

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/ejoc.200700283

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