7,8-dichloro-6-(2-fluorobenzoyl)-2,3-dihydro-1,4-benzodioxin-2-ylmethanol

Base Information

Chemical Name:7,8-dichloro-6-(2-fluorobenzoyl)-2,3-dihydro-1,4-benzodioxin-2-ylmethanol
CAS No.:103829-91-0
Molecular Formula:C₁₆H₁₁Cl₂FO₄
Molecular Weight:357.165
Hs Code.:

Synonyms:7,8-dichloro-6-(2-fluorobenzoyl)-2,3-dihydro-1,4-benzodioxin-2-ylmethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7,8-dichloro-6-(2-fluorobenzoyl)-2,3-dihydro-1,4-benzodioxin-2-ylmethanol

Chemical Property:

Purity/Quality:

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Technology Process of 7,8-dichloro-6-(2-fluorobenzoyl)-2,3-dihydro-1,4-benzodioxin-2-ylmethanol

There total 11 articles about 7,8-dichloro-6-(2-fluorobenzoyl)-2,3-dihydro-1,4-benzodioxin-2-ylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

: 120125-72-6
3,4-dichloro-1-(3-chloro-2-hydroxypropoxy)-5-(2-fluorobenzoyl)-2-hydroxybenzene

: 103829-91-0
7,8-dichloro-6-(2-fluorobenzoyl)-2,3-dihydro-1,4-benzodioxin-2-ylmethanol

Guidance literature:: With sodium hydroxide; In ethanol; for 0.166667h; Heating;
DOI:10.1248/cpb.36.3404

Reference yield:

: 3978-67-4
3,4-dichloro-1,2-benzenediol

: 103829-91-0
7,8-dichloro-6-(2-fluorobenzoyl)-2,3-dihydro-1,4-benzodioxin-2-ylmethanol

Guidance literature:: Multi-step reaction with 5 steps

1: 40.1 percent / NaH / dimethylformamide / 2 h / 100 °C

2: 79 percent / NaH / dimethylformamide / 6 h / 80 °C

3: 100 percent / H₂ / 5percent Pd-C / ethyl acetate / 0.33 h

4: 76.7 percent / 2 N NaOH / ethanol / 0.08 h / 80 °C

5: 1.) AlCl₃, 2.) 2 N NaOH / 1.) CH₂Cl₂, r.t., 30 min, 90 deg C, 2.5 h, 2.) EtOH, reflux, 30 min

With sodium hydroxide; aluminium trichloride; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.3404

Reference yield:

: 103829-60-3
2-benzyloxy-3,4-dichloro-1-hydroxybenzene

: 103829-91-0
7,8-dichloro-6-(2-fluorobenzoyl)-2,3-dihydro-1,4-benzodioxin-2-ylmethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / NaH / dimethylformamide / 6 h / 80 °C

2: 100 percent / H₂ / 5percent Pd-C / ethyl acetate / 0.33 h

3: 76.7 percent / 2 N NaOH / ethanol / 0.08 h / 80 °C

4: 1.) AlCl₃, 2.) 2 N NaOH / 1.) CH₂Cl₂, r.t., 30 min, 90 deg C, 2.5 h, 2.) EtOH, reflux, 30 min

With sodium hydroxide; aluminium trichloride; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.36.3404