N'-(N-(tert-butoxycarbonyl)-N-(2-[(tert-butoxycarbonyl)amino]ethyl)-Gly-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide

Base Information

Chemical Name:N'-(N-(tert-butoxycarbonyl)-N-(2-[(tert-butoxycarbonyl)amino]ethyl)-Gly-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide
CAS No.:870154-27-1
Molecular Formula:C₂₇H₃₆N₆O₁₀
Molecular Weight:604.617
Hs Code.:

Synonyms:N'-(N-(tert-butoxycarbonyl)-N-(2-[(tert-butoxycarbonyl)amino]ethyl)-Gly-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide

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Chemical Property of N'-(N-(tert-butoxycarbonyl)-N-(2-[(tert-butoxycarbonyl)amino]ethyl)-Gly-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide

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Technology Process of N'-(N-(tert-butoxycarbonyl)-N-(2-[(tert-butoxycarbonyl)amino]ethyl)-Gly-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide

There total 5 articles about N'-(N-(tert-butoxycarbonyl)-N-(2-[(tert-butoxycarbonyl)amino]ethyl)-Gly-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: N'-(DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide hydrochloride

: 70889-73-5
2-((tert-butoxycarbonyl)-{2-[(tert-butoxycarbonyl)amino]ethyl}amino)acetic acid

: 870154-27-1
N'-(N-(tert-butoxycarbonyl)-N-(2-[(tert-butoxycarbonyl)amino]ethyl)-Gly-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm050256l

Reference yield:

: 870154-21-5
N'-(N-tert-butoxycarbonyl-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide

: 870154-27-1
N'-(N-(tert-butoxycarbonyl)-N-(2-[(tert-butoxycarbonyl)amino]ethyl)-Gly-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. HCl / methanol / 16 h / 20 °C

2: 77 percent / PyBOP; DIEA / CH₂Cl₂ / 24 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/jm050256l

Reference yield:

: 645-12-5
5-nitro-2-furoic acid

: 870154-27-1
N'-(N-(tert-butoxycarbonyl)-N-(2-[(tert-butoxycarbonyl)amino]ethyl)-Gly-DL-phenylglycinyl)-5-nitro-2-furancarbohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: 71 percent / PyBOP; DIEA / CH₂Cl₂ / 16 h / 20 °C

2: 95 percent / aq. HCl / methanol / 16 h / 20 °C

3: 70 percent / PyBOP; DIEA / CH₂Cl₂ / 24 h / 20 °C

4: 95 percent / aq. HCl / methanol / 16 h / 20 °C

5: 77 percent / PyBOP; DIEA / CH₂Cl₂ / 24 h / 20 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1021/jm050256l