3-(2-hydroxy-5-carboxyphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole

Base Information

Chemical Name:3-(2-hydroxy-5-carboxyphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole
CAS No.:912967-91-0
Molecular Formula:C₁₇H₁₁F₃N₂O₃
Molecular Weight:348.281
Hs Code.:

Synonyms:3-(2-hydroxy-5-carboxyphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole

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Chemical Property of 3-(2-hydroxy-5-carboxyphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole

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Technology Process of 3-(2-hydroxy-5-carboxyphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole

There total 5 articles about 3-(2-hydroxy-5-carboxyphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(2-hydroxy-5-methoxycarbonylphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole

: 912967-91-0
3-(2-hydroxy-5-carboxyphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole

Guidance literature:: 3-(2-hydroxy-5-methoxycarbonylphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole; With water; sodium hydroxide; In propan-1-ol; at 65 ℃; for 4h;

With potassium hydrogensulfate; In propan-1-ol; water; ethyl acetate;

Reference yield:

: 912968-07-1
1-(2-hydroxy-5-methoxycarbonylphenyl)-3-(4-(trifluoromethyl)phenyl)propane-1,3-dione

: 912967-91-0
3-(2-hydroxy-5-carboxyphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / tetrahydrofuran; propan-1-ol; water / 2 h / 65 °C

2: water / sodium hydroxide / propan-1-ol / 4 h / 65 °C

With water; hydrazine; sodium hydroxide; In tetrahydrofuran; propan-1-ol; water;

Reference yield:

: 912968-06-0
4-trifluoromethyl-(2'-acetyl-4'-methoxycarbonyl)phenyl benzoate

: 912967-91-0
3-(2-hydroxy-5-carboxyphenyl)-5-(4-(trifluoromethyl)phenyl)-(1H)-pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran; N,N-dimethyl-formamide / 1.5 h / 10 °C

2: hydrazine / tetrahydrofuran; propan-1-ol; water / 2 h / 65 °C

3: water / sodium hydroxide / propan-1-ol / 4 h / 65 °C

With potassium tert-butylate; water; hydrazine; sodium hydroxide; In tetrahydrofuran; propan-1-ol; water; N,N-dimethyl-formamide;