tert-butyl (1R,2S)-2-formyl-2-methyl-1-phenylcyclopropanecarboxylate

Base Information

• Chemical Name: tert-butyl (1R,2S)-2-formyl-2-methyl-1-phenylcyclopropanecarboxylate
• CAS No.: 1350706-88-5
• Molecular Formula: C₁₆H₂₀O₃
• Molecular Weight: 260.333
• Mol file: 1350706-88-5.mol

Synonyms:tert-butyl (1R,2S)-2-formyl-2-methyl-1-phenylcyclopropanecarboxylate

Chemical Property of tert-butyl (1R,2S)-2-formyl-2-methyl-1-phenylcyclopropanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-butyl (1R,2S)-2-formyl-2-methyl-1-phenylcyclopropanecarboxylate

There total 6 articles about tert-butyl (1R,2S)-2-formyl-2-methyl-1-phenylcyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-methylpropenal (78-85-3,25120-30-3) + tert-butyl 2-diazo-2-phenylacetate (72410-67-4) → tert-butyl (1R,2S)-2-formyl-2-methyl-1-phenylcyclopropanecarboxylate (1350706-88-5)

Guidance literature:

With CHF₃O₃S*C₃₁H₃₂BNO; at -45 ℃; for 0.5h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/jacs.1c03211

Reference yield: 71.0%

2-methylpropenal (78-85-3,25120-30-3) + tert-butyl 2-diazo-2-phenylacetate (72410-67-4) → tert-butyl (1R,2S)-2-formyl-2-methyl-1-phenylcyclopropanecarboxylate (1350706-88-5) + tert-butyl 2-formyl-2-methyl-1-phenylcyclopropanecarboxylate

Guidance literature:

With CHF₃O₃S*C₃₁H₃₂BNO; In propiononitrile; at -45 - 0 ℃; for 8.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja209270e

Reference yield: 63.0%

2-methylpropenal (78-85-3,25120-30-3) + tert-butyl 2-diazo-2-phenylacetate (72410-67-4) → C16H20N2O3 (1350707-91-3) + tert-butyl (1R,2S)-2-formyl-2-methyl-1-phenylcyclopropanecarboxylate (1350706-88-5) + tert-butyl 2-formyl-2-methyl-1-phenylcyclopropanecarboxylate

Guidance literature:

With CHF₃O₃S*C₃₁H₃₂BNO; In propiononitrile; at -45 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ja209270e

upstream raw materials:

2-methylpropenal

tert-butyl 2-diazo-2-phenylacetate

t-butyl phenylacetate