N-[5-(4-fluoro-2-methoxyphenyl)pyridazin-4-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethylbenzamide

Base Information

Chemical Name:N-[5-(4-fluoro-2-methoxyphenyl)pyridazin-4-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethylbenzamide
CAS No.:1466574-24-2
Molecular Formula:C₂₁H₁₇F₄N₃O₄S
Molecular Weight:483.443
Hs Code.:

Synonyms:N-[5-(4-fluoro-2-methoxyphenyl)pyridazin-4-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethylbenzamide

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Chemical Property of N-[5-(4-fluoro-2-methoxyphenyl)pyridazin-4-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethylbenzamide

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Technology Process of N-[5-(4-fluoro-2-methoxyphenyl)pyridazin-4-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethylbenzamide

There total 3 articles about N-[5-(4-fluoro-2-methoxyphenyl)pyridazin-4-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 1395416-72-4
3-(methylsulfonyl)-5-(trifluoromethyl)benzoyl chloride

: 1466574-73-1
5-(4-fluoro-2-methoxyphenyl)-N-methylpyridazin-4-amine

: 1466574-24-2
N-[5-(4-fluoro-2-methoxyphenyl)pyridazin-4-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.75h;

Reference yield:

: 1215205-96-1
1-bromo-3-(methylsulfonyl)-5-(trifluoromethyl)benzene

: 1466574-24-2
N-[5-(4-fluoro-2-methoxyphenyl)pyridazin-4-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine / ethyl acetate / 20 h / 110 °C / 52505.3 Torr

2: water; lithium hydroxide monohydrate / 1,4-dioxane / 2 h / 20 °C

3: thionyl chloride / N,N-dimethyl-formamide / 0.5 h / Reflux

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.75 h / 20 °C

With thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; lithium hydroxide monohydrate; water; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 53985-43-6
3-methanesulfonyl-5-trifluoromethylbenzoic acid

: 1466574-24-2
N-[5-(4-fluoro-2-methoxyphenyl)pyridazin-4-yl]-3-methanesulfonyl-N-methyl-5-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / N,N-dimethyl-formamide / 0.5 h / Reflux

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1.75 h / 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;