4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol

Base Information

Chemical Name:4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol
CAS No.:1146161-64-9
Molecular Formula:C₁₉H₁₉FN₄O₂
Molecular Weight:354.384
Hs Code.:

Synonyms:4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol

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Chemical Property of 4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol

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Technology Process of 4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol

There total 9 articles about 4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 254881-77-1,1018667-18-9
1-tert-butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate

: 1146161-64-9
4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane

2.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.08 h / 0 °C

2.2: 0.5 h

3.1: hydrogenchloride / 1,4-dioxane / 1 h

With hydrogenchloride; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1021/jm101150b

Reference yield:

: C₂₄H₂₇FN₄O₄

: 1146161-64-9
4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol

Guidance literature:: C₂₄H₂₇FN₄O₄; With lithium aluminium tetrahydride; In 1,4-dioxane; for 1h;

With ammonia; In methanol;

Reference yield:

: 1146161-62-7
1-tert-butyl 2-methyl (2R,4S)-4-(2-(5-fluoro-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1,2-dicarboxylate

: 1146161-64-9
4-fluoro-2-(4-((3S,5R)-5-(hydroxymethyl)pyrrolidin-3-ylamino)quinazolin-2-yl)phenol

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran; diethyl ether / 0.08 h / 0 °C

1.2: 0.5 h

2.1: hydrogenchloride / 1,4-dioxane / 1 h

With hydrogenchloride; lithium aluminium tetrahydride; In tetrahydrofuran; 1,4-dioxane; diethyl ether;
DOI:10.1021/jm101150b