2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-propane-1,3-diol

Base Information

• Chemical Name: 2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-propane-1,3-diol
• CAS No.: 191660-25-0
• Molecular Formula: C₂₃H₃₄O₃Si
• Molecular Weight: 386.607

Synonyms:2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-propane-1,3-diol

Chemical Property of 2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-propane-1,3-diol

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Technology Process of 2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-propane-1,3-diol

There total 2 articles about 2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-malonic acid → 2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-propane-1,3-diol (191660-25-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 4h; Yield given;

DOI:10.1016/S0040-4039(97)00945-3

Reference yield:

(2S)-(tert-butyl)(3-iodo-2-methylpropoxy)diphenylsilane (72297-78-0) → 2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-propane-1,3-diol (191660-25-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / toluene; dimethylformamide / 5 h / 80 °C

2: LAH / tetrahydrofuran / 4 h / 0 °C

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0040-4039(97)00945-3

Reference yield: 93.0%

vinyl acetate (108-05-4,9003-20-7) + 2-[(R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-methyl-propyl]-propane-1,3-diol (191660-25-0) → Acetic acid (2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2-hydroxymethyl-4-methyl-pentyl ester (191660-26-1)

Guidance literature:

With pig pancrease lipase; In tetrahydrofuran; for 336h; Ambient temperature;

DOI:10.1016/S0040-4039(97)00945-3

upstream raw materials:

(2S)-(tert-butyl)(3-iodo-2-methylpropoxy)diphenylsilane

Downstream raw materials:

Acetic acid (2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2-hydroxymethyl-4-methyl-pentyl ester

(3R,5R)-6-(tert-Butyl-diphenyl-silanyloxy)-3-hydroxymethyl-5-methyl-hexanenitrile

Acetic acid (2R,4R)-5-(tert-butyl-diphenyl-silanyloxy)-2-cyanomethyl-4-methyl-pentyl ester

(3R,5R)-3-Benzenesulfonylmethyl-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hexanenitrile

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