(4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol

Base Information

• Chemical Name: (4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol
• CAS No.: 854749-31-8
• Molecular Formula: C₃₆H₅₂O₄Si₂
• Molecular Weight: 604.977
• Mol file: 854749-31-8.mol

Synonyms:(4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol

Chemical Property of (4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol

There total 7 articles about (4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-1-(tert-butyldiphenylsilyloxy)hex-5-en-3-ol (112897-09-3) → (4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol (854749-31-8)

Guidance literature:

Multi-step reaction with 3 steps

1: KHMDS

2: O₃

3: 100 percent / MgBr₂*Et₂O / -78 °C

With potassium hexamethylsilazane; ozone; magnesium bromide;

DOI:10.1021/ol050512o

Reference yield:

(R)-tert-butyl-(3-(4-methoxybenzyloxy)hex-5-enyloxy)-diphenylsilane (633305-66-5) → (4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol (854749-31-8)

Guidance literature:

Multi-step reaction with 2 steps

1: O₃

2: 100 percent / MgBr₂*Et₂O / -78 °C

With ozone; magnesium bromide;

DOI:10.1021/ol050512o

Reference yield:

3-(tert-butyldiphenylsilyloxy)-1-propanal (112897-03-7) → (4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol (854749-31-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / (R)-BITIP

2: KHMDS

3: O₃

4: 100 percent / MgBr₂*Et₂O / -78 °C

With (R)-BITIP; potassium hexamethylsilazane; ozone; magnesium bromide;

DOI:10.1021/ol050512o

upstream raw materials:

3-(tert-butyldiphenylsilyloxy)-1-propanal

(3R)-1-(tert-butyldiphenylsilyloxy)hex-5-en-3-ol

(R)-tert-butyl-(3-(4-methoxybenzyloxy)hex-5-enyloxy)-diphenylsilane

p-Methoxybenzyl bromide

Downstream raw materials:

C₅₆H₈₀O₁₂

C₅₆H₈₀O₁₂

C₄₈H₆₆O₁₁

(2S,6S)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(tert-butyldimethylsilyloxy)butyl)-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-(tert-butyldimethylsilyloxy)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl) tetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-2-methoxydihydro-2H-pyran-3(4H)-one