(+)-(2R,3S)-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-[(4-methoxyphenyl)amino]-N-methyl-3-phenylpropanamide

Base Information

• Chemical Name: (+)-(2R,3S)-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-[(4-methoxyphenyl)amino]-N-methyl-3-phenylpropanamide
• CAS No.: 925206-28-6
• Molecular Formula: C₂₈H₃₄N₂O₃
• Molecular Weight: 446.59

Synonyms:(+)-(2R,3S)-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-[(4-methoxyphenyl)amino]-N-methyl-3-phenylpropanamide

Chemical Property of (+)-(2R,3S)-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-[(4-methoxyphenyl)amino]-N-methyl-3-phenylpropanamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of (+)-(2R,3S)-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-[(4-methoxyphenyl)amino]-N-methyl-3-phenylpropanamide

There total 2 articles about (+)-(2R,3S)-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-[(4-methoxyphenyl)amino]-N-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(1S,2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylbutyramide (234446-83-4) + [4-(benzylideneamino)phenyl]methanol (783-08-4) → (+)-(2R,3S)-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-[(4-methoxyphenyl)amino]-N-methyl-3-phenylpropanamide (925206-28-6)

Guidance literature:

(1S,2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylbutyramide; With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 1h;

[4-(benzylideneamino)phenyl]methanol; In tetrahydrofuran; at 0 ℃; Further stages.;

DOI:10.1055/s-2006-950347

Reference yield:

C28H34N2O3 → (+)-(2R,3S)-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-[(4-methoxyphenyl)amino]-N-methyl-3-phenylpropanamide (925206-28-6)

Guidance literature:

for 24h;

DOI:10.1055/s-2006-950347

Reference yield: 98.0%

(+)-(2R,3S)-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-3-[(4-methoxyphenyl)amino]-N-methyl-3-phenylpropanamide (925206-28-6) + di-tert-butyl dicarbonate (24424-99-5) → (+)-(2R,3S)-3-[(tert-butoxycarbonyl)(4-methoxyphenyl)amino]-2-ethyl-N-[(1S,2S)-2-hydroxy-1-methyl-1-phenylethyl]-N-methyl-3-phenylpropanamide

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; for 1h; Heating;

DOI:10.1055/s-2006-950347

upstream raw materials:

(1S,2S)-N-(2-hydroxy-1-methyl-2-phenylethyl)-N-methylbutyramide

[4-(benzylideneamino)phenyl]methanol

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