2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

Base Information

Chemical Name:2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin
CAS No.:142864-98-0
Molecular Formula:C₂₀H₃₀O₂S
Molecular Weight:334.523
Hs Code.:

Synonyms:2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

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Chemical Property of 2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

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Technology Process of 2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

There total 6 articles about 2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 79563-61-4
1-((2R,4aR,7R,8aR)-4,4,7-Trimethyl-hexahydro-1-oxa-3-thia-naphthalen-2-yl)-propan-1-one

: phenylmagnesium bromide

: 89556-33-2
2-<(1'S)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

: 142864-98-0
2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 4h; Title compound not separated from byproducts;
DOI:10.1021/jo00045a032

Reference yield:

: phenylmagnesium bromide

: 142864-98-0
2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

Guidance literature:: Multi-step reaction with 4 steps

1: 75 mg / tetrahydrofuran / 4 h / -78 °C / or with phenyllithium

2: 35 mg / tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature

3: 19 mg / pyridine / 1) 0 deg C, 30 min, 2) 4 deg C, 3 d

4: LiAlH₄ / tetrahydrofuran / 6.5 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jo00045a032

Reference yield:

: 142864-93-5
2-<(2'R)-2'-(triisopropylsiloxy)propanoyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

: 142864-98-0
2-<(1'R)-1'-hydroxy-1'-phenylpropyl>hexahydro-4,4,7-trimethyl-4H-1,3-benzoxathiin

Guidance literature:: Multi-step reaction with 4 steps

1: 75 mg / tetrahydrofuran / 4 h / -78 °C / or with phenyllithium

2: 35 mg / tetrabutylammonium fluoride / tetrahydrofuran / Ambient temperature

3: 19 mg / pyridine / 1) 0 deg C, 30 min, 2) 4 deg C, 3 d

4: LiAlH₄ / tetrahydrofuran / 6.5 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/jo00045a032