(R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride

Base Information

Chemical Name:(R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride
CAS No.:1597414-61-3
Molecular Formula:C₂₆H₂₄N₆O₉S*ClH
Molecular Weight:633.038
Hs Code.:

Synonyms:(R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride

Suppliers and Price of (R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride

There total 13 articles about (R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1597414-60-2
C₄₀H₃₆N₆O₉S*ClH

: 1597414-61-3
(R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride

Guidance literature:: C₄₀H₃₆N₆O₉S*ClH; With hydrogen; palladium(II) hydroxide; acetic acid; In water; at 45 ℃; under 862.586 - 900.09 Torr;

With acetic acid; In water; at 0 - 80 ℃; for 6h; Reagent/catalyst;

Reference yield:

: 61874-04-2
(3-formyl-4-hydroxyphenyl)acetic acid methyl ester

: 1597414-61-3
(R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane

3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane

4.1: lithium hydroxide; isopropyl alcohol

5.1: sodium metabisulfite; C₄H₄Cl₂N₂Pd^(2-) / isopropyl alcohol; water

6.1: hydrogenchloride; acetic acid; water / Reflux

7.1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / -5 °C

7.2: 10 - 45 °C

8.1: acetic acid; hydrogen; palladium(II) hydroxide / water / 45 °C / 862.59 - 900.09 Torr

8.2: 6 h / 0 - 80 °C

With 4-methyl-morpholine; hydrogenchloride; sodium metabisulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; C₄H₄Cl₂N₂Pd^(2-); water; hydrogen; palladium(II) hydroxide; acetic acid; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1597414-61-3
(R)-2-{2-[5-(5-carbamimidoyl-1H-benzimidazol-2-yl)-6,2'-dihydroxy-5'-sulfamoylbiphenyl-3-yl]acetylamino}succinic acid hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine; magnesium chloride / acetonitrile

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dichloromethane

5.1: lithium hydroxide; isopropyl alcohol

6.1: sodium metabisulfite; C₄H₄Cl₂N₂Pd^(2-) / isopropyl alcohol; water

7.1: hydrogenchloride; acetic acid; water / Reflux

8.1: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / -5 °C

8.2: 10 - 45 °C

9.1: acetic acid; hydrogen; palladium(II) hydroxide / water / 45 °C / 862.59 - 900.09 Torr

9.2: 6 h / 0 - 80 °C

With 4-methyl-morpholine; hydrogenchloride; sodium metabisulfite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; C₄H₄Cl₂N₂Pd^(2-); water; hydrogen; palladium(II) hydroxide; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; magnesium chloride; lithium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;