(1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)-4-butanal

Base Information

Chemical Name:(1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)-4-butanal
CAS No.:1316841-33-4
Molecular Formula:C₁₆H₂₄O₅
Molecular Weight:296.364
Hs Code.:

Synonyms:(1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)-4-butanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)-4-butanal

Chemical Property:

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Technology Process of (1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)-4-butanal

There total 8 articles about (1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)-4-butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1316841-30-1
(1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)pentan-4,5-diol

: 1316841-33-4
(1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)-4-butanal

Guidance literature:: With sodium periodate; In methanol; water; for 0.5h;
DOI:10.1021/jo200968f

Reference yield:

: 1316841-32-3
(1R,2R,3S)-1-(3,4-dimethoxyphenyl)-2,3-dimethylpent-4-en-1-ol

: 1316841-33-4
(1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)-4-butanal

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol / 48 h / 20 °C

3: sodium periodate / methanol; water / 0.5 h

With sodium periodate; osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jo200968f

Reference yield:

: C₇H₁₁IO₂

: 1316841-33-4
(1R,2R,3R)-1-(3,4-dimethoxyphenyl)-2,3-dimethyl-1-(methoxymethoxy)-4-butanal

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid; zinc / 18 h / 60 °C

2.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 22 h / 0 - 20 °C / Inert atmosphere

3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / methanol / -78 - 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / tert-butyl alcohol / 48 h / 20 °C

7.1: sodium periodate / methanol; water / 0.5 h

With dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; water; tert.-butyl lithium; acetic acid; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol; pentane;
DOI:10.1021/jo200968f