2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid HCl salt

Base Information

Chemical Name:2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid HCl salt
CAS No.:924644-53-1
Molecular Formula:C₁₅H₁₅FN₂O₄*ClH
Molecular Weight:342.754
Hs Code.:

Synonyms:2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid HCl salt

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Chemical Property of 2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid HCl salt

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Technology Process of 2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid HCl salt

There total 5 articles about 2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid HCl salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 924644-52-0
2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid methyl ester

: 924644-53-1
2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid HCl salt

Guidance literature:: 2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid methyl ester; With sodium hydroxide; In tetrahydrofuran; water; at 70 ℃; for 3h;

With hydrogenchloride; pH=1;

Reference yield:

: 1396997-08-2
2-(2-fluorobenzoylamino)propionic acid

: 924644-53-1
2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid HCl salt

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 16 h / 20 °C

1.2: 20 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Heating / reflux

3.1: triethylamine / dichloromethane / 20 °C

4.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 70 °C

4.2: pH 1

With sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; water;

Reference yield:

: 924644-50-8
2-(2-fluorophenyl)-4-methyloxazole-5-carboxylic acid methyl ester

: 924644-53-1
2-(2-fluorophenyl)-4-(morpholin-4-ylmethyl)-oxazole-5-carboxylic acid HCl salt

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / Heating / reflux

2.1: triethylamine / dichloromethane / 20 °C

3.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 70 °C

3.2: pH 1

With sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; water;