Technology Process of 5-Chlorothiophene-3-carbonyl chloride
There total 2 articles about 5-Chlorothiophene-3-carbonyl chloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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5-Chlor-thiophen-3-carbonsaeure, SOCl2 (exotherm. Rk., dann Siedetemp., 4 Std.); nicht rein isoliert;
- Guidance literature:
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Multi-step reaction with 3 steps
1: n-butyllithium / toluene
2: potassium permanganate; water; sodium hydrogencarbonate; magnesium sulfate / acetone
3: water; sodium carbonate / 1,4-dioxane; ethanol
With
potassium permanganate; n-butyllithium; water; sodium hydrogencarbonate; sodium carbonate; magnesium sulfate;
In
1,4-dioxane; ethanol; acetone; toluene;
DOI:10.1016/j.bmcl.2011.07.057