6-chloro-N_α-acetyltryptophan methyl ester

Base Information

• Chemical Name: 6-chloro-N_α-acetyltryptophan methyl ester
• CAS No.: 1034402-47-5
• Molecular Formula: C₁₄H₁₅ClN₂O₃
• Molecular Weight: 294.738
• Mol file: 1034402-47-5.mol

Synonyms:6-chloro-N_α-acetyltryptophan methyl ester

Chemical Property of 6-chloro-N_α-acetyltryptophan methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 6-chloro-N_α-acetyltryptophan methyl ester

There total 4 articles about 6-chloro-N_α-acetyltryptophan methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

6-chloroindole (17422-33-2) + Methyl 2-acetamidoacrylate (35356-70-8) → 6-chloro-Nα-acetyltryptophan methyl ester (1034402-47-5,1235280-35-9)

Guidance literature:

With ethylaluminum dichloride; In hexane; dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/jo800881u

Reference yield:

Nα-acetyl-6-chloro-D,L-tryptophan (50517-10-7) + diazomethyl-trimethyl-silane (18107-18-1) → 6-chloro-Nα-acetyltryptophan methyl ester (1034402-47-5,1235280-35-9)

Guidance literature:

With acetic anhydride; acetic acid; In methanol; ethyl acetate; toluene; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2012.12.028

Reference yield:

6-chloroindole (17422-33-2) → 6-chloro-Nα-acetyltryptophan methyl ester (1034402-47-5,1235280-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / 3 h / 45 °C

1.2: Heating

2.1: acetic acid; acetic anhydride / methanol; ethyl acetate; toluene / 1 h / 20 °C

With acetic anhydride; acetic acid; In methanol; ethyl acetate; toluene; 1.2: |Michael Addition;

DOI:10.1016/j.bmc.2012.12.028

upstream raw materials:

6-chloroindole

Methyl 2-acetamidoacrylate

N^α-acetyl-6-chloro-D,L-tryptophan

diazomethyl-trimethyl-silane