(E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal

Base Information

Chemical Name:(E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal
CAS No.:180740-60-7
Molecular Formula:C₃₄H₄₄O₂Si
Molecular Weight:512.808
Hs Code.:

Synonyms:(E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal

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Chemical Property of (E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal

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Technology Process of (E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal

There total 8 articles about (E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 180740-59-4
(E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enenitrile

: 180740-60-7
(E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1021/jo971409i

Reference yield:

: 180740-53-8
1-[3-tert-butyl-5-(1-hydroxyethyl)phenyl]ethanol

: 180740-60-7
(E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / NaH / tetrahydrofuran / 2.5 h

2: 98 percent / PCC, Celite / CH₂Cl₂ / 3 h / Ambient temperature

4: 1.76 g / NaBH₄ / methanol / 0.5 h / Ambient temperature

5: MnO₂ / CH₂Cl₂ / 4 h

6: 78 percent / imidazole, DMF / CH₂Cl₂ / Ambient temperature

7: 63 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h

8: 75 percent / DIBAL / CH₂Cl₂ / 1 h / -78 °C

With 1H-imidazole; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; Celite; sodium hydride; diisobutylaluminium hydride; N,N-dimethyl-formamide; pyridinium chlorochromate; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo971409i

Reference yield:

: 180740-56-1
1-[3-tert-butyl-5-(1-hydroxyethyl)phenyl]-2-methylpropionaldehyde

: 180740-60-7
(E)-3-{3-tert-Butyl-5-[2-(tert-butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-phenyl}-but-2-enal

Guidance literature:: Multi-step reaction with 5 steps

1: 1.76 g / NaBH₄ / methanol / 0.5 h / Ambient temperature

2: MnO₂ / CH₂Cl₂ / 4 h

3: 78 percent / imidazole, DMF / CH₂Cl₂ / Ambient temperature

4: 63 percent / n-BuLi / tetrahydrofuran; hexane / 0.5 h

5: 75 percent / DIBAL / CH₂Cl₂ / 1 h / -78 °C

With 1H-imidazole; manganese(IV) oxide; sodium tetrahydroborate; n-butyllithium; diisobutylaluminium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1021/jo971409i