4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester

Base Information

Chemical Name:4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester
CAS No.:199989-51-0
Molecular Formula:C₂₀H₂₆N₂O₃
Molecular Weight:342.438
Hs Code.:

Synonyms:4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester

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Chemical Property of 4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester

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Technology Process of 4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester

There total 7 articles about 4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199989-50-9
(E)-4-[5-Ethyl-1-methyl-4-(3-nitro-benzoyl)-1H-pyrrol-2-yl]-but-2-enoic acid ethyl ester

: 199989-51-0
4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 0.5h; under 1471.02 Torr;
DOI:10.1248/cpb.45.1767

Reference yield:

: 1551-06-0
2-ethyl-1H-pyrrole

: 199989-51-0
4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) oxalyl chloride, 3.) AlCl₃

2: K₂CO₃ / dimethylformamide / 1 h / Ambient temperature

3: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 20 min, 2.) THF, RT, 20 min

4: HCl / tetrahydrofuran; dioxane / 0.5 h

5: dimethylformamide / 1.5 h / Ambient temperature

6: H₂ / 10percent Pd/C / ethanol / 0.5 h / 1471.02 Torr

With hydrogenchloride; aluminium trichloride; oxalyl dichloride; potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1767

Reference yield:

: 121-90-4
m-nitrobenzoic acid chloride

: 199989-51-0
4-[4-(3-Amino-benzoyl)-5-ethyl-1-methyl-1H-pyrrol-2-yl]-butyric acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) oxalyl chloride, 3.) AlCl₃

2: K₂CO₃ / dimethylformamide / 1 h / Ambient temperature

3: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 20 min, 2.) THF, RT, 20 min

4: HCl / tetrahydrofuran; dioxane / 0.5 h

5: dimethylformamide / 1.5 h / Ambient temperature

6: H₂ / 10percent Pd/C / ethanol / 0.5 h / 1471.02 Torr

With hydrogenchloride; aluminium trichloride; oxalyl dichloride; potassium tert-butylate; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1767