2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester

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Chemical Name:2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester
CAS No.:1532530-87-2
Molecular Formula:C₄₂H₅₆N₆O₅Si
Molecular Weight:753.029
Hs Code.:

2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester

Synonyms:2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester

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Chemical Property of 2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester

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Technology Process of 2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester

There total 7 articles about 2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1179149-98-4
2-[5-bromo-1-(2-trimethylsilanyl-ethoxymethyl)-1Himidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1256386-42-1
(S)-4-((2-(1-(tert-butoxycarbonyl)pyrrolidin-2-yl)-1H-benzo[d]imidazol-6-yl)ethynyl)phenylboronic acid

: 1532530-87-2
2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 0.5h;
DOI:10.1021/jm401499g

Reference yield:

: 2-[6-(4-iodophenylethynyl)-1H-benzoimidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1532530-87-2
2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 90 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; potassium carbonate; In 1,4-dioxane; 1,2-dimethoxyethane; water; 1: |Miyaura Borylation Reaction / 2: |Suzuki Coupling;
DOI:10.1021/jm401499g

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1532530-87-2
2-(6-{4-[2-(1-boc-pyrrolidin-2-yl)-3-(2-trimethylsilanylethoxymethyl)-3H-imidazol-4-yl]-phenylethynyl}-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tertbutylester

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 1 h / 80 °C / Microwave irradiation

2: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 8 h / 80 °C

3: potassium carbonate / methanol / 2 h / 20 °C

4: triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation

5: potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 5 h / 90 °C

6: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 0.5 h / 90 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium acetate; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling / 4: |Sonogashira Cross-Coupling / 5: |Miyaura Borylation Reaction / 6: |Suzuki Coupling;
DOI:10.1021/jm401499g