Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)
• CAS No.: 113337-39-6
• Molecular Formula: C9H8 Cl2 O
• Molecular Weight: 203.068
• Mol file: 113337-39-6.mol

Synonyms:Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)

Chemical Property of Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)

Chemical Property:

• PSA: 17.07000
• LogP: 2.98140

Purity/Quality:

2,2-dichloro-1-(o-tolyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)

There total 11 articles about Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-ethynyl-2-methylbenzene (766-47-2) → α,α-dichloro-o-methylacetophenone (113337-39-6)

Guidance literature:

With trichloroisocyanuric acid; p-methylphenylthiourea; water; at 20 ℃; for 0.333333h; chemoselective reaction; Sealed tube; Sonication; Green chemistry;

DOI:10.1016/j.tet.2017.05.075

Reference yield: 85.0%

3-(2-methylphenyl)propionamide-3-one → α,α-dichloro-o-methylacetophenone (113337-39-6)

Guidance literature:

With N-chloro-succinimide; potassium tert-butylate; In tetrahydrofuran; at 80 ℃; for 4h; Reagent/catalyst;

DOI:10.1016/j.tetlet.2016.12.087

Reference yield: 84.0%

3-(dimethylamino)-1-(2-tolyl)-2-propen-1-one (921845-62-7) → α,α-dichloro-o-methylacetophenone (113337-39-6)

Guidance literature:

With hydrogenchloride; In water; acetonitrile; at 20 ℃; for 3h; Electrolysis;

DOI:10.1016/j.tetlet.2021.153575

upstream raw materials:

1-methyl-2-vinyl-benzene

2-Methylacetophenone

3-oxo-3-(o-tolyl)propanenitrile

ethyl 2-methylbenzoate

Downstream raw materials:

C₉H₁₀Cl₂O

C₉H₁₀Cl₂O

C₉H₁₀Cl₂O

Refernces

• 1、 Zhang, Zhenlei,Yang, Jiusi,Wu, Kairui,Yu, Renjie,Bu, Jiping,Huang, Zijun,Li, Shaoke,Ma, Xiantao. "Access to α,α-dihaloacetophenones through anodic C[dbnd]C bond cleavage in enaminones". . . Retrieved 2021/12/20.
• 2、 Tu, Dewei,Luo, Juan,Jiang, Wengao,Tang, Qiang. "Solvent-free preparation of α,α-dichloroketones with sulfuryl chloride". supporting information. . Retrieved 2021/09/15.