1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole hydrochloride

Base Information

Chemical Name:1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole hydrochloride
CAS No.:124750-09-0
Molecular Formula:C₂₂H₂₄N₂O₃*ClH
Molecular Weight:400.905
Hs Code.:

Synonyms:1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole hydrochloride

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Chemical Property of 1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole hydrochloride

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Technology Process of 1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole hydrochloride

There total 14 articles about 1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 124750-55-6
1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole

: 124750-09-0
1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole hydrochloride

Guidance literature:: With hydrogenchloride; at 25 ℃; for 16h;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 124750-09-0
1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: oxalyl chloride / CH₂Cl₂ / 3 h / 25 °C

4: tetrahydrofuran / 1 h / 25 °C

5: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

6: potassium carbonate / dimethylformamide / 24 h / 25 °C

7: 96 percent / sodium borohydride / methanol; tetrahydrofuran / 1.5 h / 25 °C

8: 70 percent / 10percent aq. HCl / 16 h / 25 °C

With hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; oxalyl dichloride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a031

Reference yield:

: 7148-03-0
o-tolylbenzoic acid

: 124750-09-0
1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-methyl-2-propylimidazole hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: oxalyl chloride / CH₂Cl₂ / 3 h / 25 °C

2: tetrahydrofuran / 1 h / 25 °C

3: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

4: potassium carbonate / dimethylformamide / 24 h / 25 °C

5: 96 percent / sodium borohydride / methanol; tetrahydrofuran / 1.5 h / 25 °C

6: 70 percent / 10percent aq. HCl / 16 h / 25 °C

With hydrogenchloride; sodium tetrahydroborate; N-Bromosuccinimide; oxalyl dichloride; potassium carbonate; dibenzoyl peroxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a031