N-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide

Base Information

Chemical Name:N-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide
CAS No.:477289-52-4
Molecular Formula:C₁₇H₂₂N₂O₅S₂
Molecular Weight:398.504
Hs Code.:

<i>N</i>-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide

Synonyms:N-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide

Chemical Property:

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Technology Process of N-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide

There total 6 articles about N-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: Methanesulfonic acid 4-[(S)-3-methanesulfonylamino-2-(toluene-4-sulfonylamino)-propyl]-phenyl ester

: 477289-52-4
N-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide

Guidance literature:: With potassium carbonate; In methanol; at 60 ℃; Inert atmosphere;
DOI:10.1002/chem.201001402

Reference yield:

: (S)-N-[1-hydroxymethyl-2-(4-hydroxy-phenyl)-ethyl]-toluene-4-sulfonamide

: 477289-52-4
N-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: TEA / CH₂Cl₂

2: NaN₃ / dimethylformamide

3: H₂ / Pd(c) / tetrahydrofuran

4: TEA / CH₂Cl₂

5: NaOH / H₂O; dioxane

With sodium hydroxide; sodium azide; TEA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)00949-8

Reference yield:

: 101585-61-9
N-tosyl L-tyrosine methyl ester

: 477289-52-4
N-[2-(4-hydroxy-phenyl)-1-(methanesulfonylamino-methyl)-ethyl]-4-methyl-benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: LAH

2: TEA / CH₂Cl₂

3: NaN₃ / dimethylformamide

4: H₂ / Pd(c) / tetrahydrofuran

5: TEA / CH₂Cl₂

6: NaOH / H₂O; dioxane

With sodium hydroxide; lithium aluminium tetrahydride; sodium azide; TEA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(02)00949-8