Technology Process of 4-(2,2-bis(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-isobutylbenzoic acid
There total 7 articles about 4-(2,2-bis(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-isobutylbenzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2,2-bis(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-isobutylbenzoic acid methyl ester;
With
sodium hydroxide;
In
methanol;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
methanol; water;
pH=2;
DOI:10.1016/j.bmc.2012.05.001
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene-4-sulfonic acid / toluene / 19 h / Molecular sieve; Reflux
2.1: sodium tetrahydroborate; acetic acid / 1,2-dichloro-ethane / 15 h / 20 °C
3.1: phosphorus trichloride / toluene / 20 h / 100 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 20 °C
5.1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 4 h / 25 °C / 760.05 Torr
6.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 0 - 20 °C / Inert atmosphere
7.1: sodium hydroxide / methanol / 2 h / 20 °C
7.2: pH 2
With
sodium tetrahydroborate; 5%-palladium/activated carbon; hydrogen; sodium hydride; toluene-4-sulfonic acid; acetic acid; sodium hydroxide; phosphorus trichloride;
In
tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.05.001
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate; acetic acid / 1,2-dichloro-ethane / 15 h / 20 °C
2.1: phosphorus trichloride / toluene / 20 h / 100 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 20 °C
4.1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran / 4 h / 25 °C / 760.05 Torr
5.1: sodium tetrahydroborate / tetrahydrofuran; methanol / 2 h / 0 - 20 °C / Inert atmosphere
6.1: sodium hydroxide / methanol / 2 h / 20 °C
6.2: pH 2
With
sodium tetrahydroborate; 5%-palladium/activated carbon; hydrogen; sodium hydride; acetic acid; sodium hydroxide; phosphorus trichloride;
In
tetrahydrofuran; methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2012.05.001
