(4S,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one

Base Information

Chemical Name:(4S,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one
CAS No.:410077-37-1
Molecular Formula:C₂₃H₂₉IO₄Si
Molecular Weight:524.471
Hs Code.:

Synonyms:(4S,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one

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Chemical Property of (4S,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one

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Technology Process of (4S,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one

There total 3 articles about (4S,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 410077-35-9
carbonic acid tert-butyl ester 1-(tert-butyl-diphenyl-silanyloxymethyl)-1-methyl-but-3-enyl ester

: 410077-37-1
(4S,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one

: (4S,6S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one

Guidance literature:: With iodine(I) bromide; In diethyl ether; dichloromethane; at -100 - -78 ℃; for 5.5h; optical yield given as %de; Inert atmosphere;
DOI:10.1016/j.tet.2009.04.003

Reference yield:

: 184091-30-3
(S)-1-(tert-butyldiphenylsilyloxy)methyl-1-methyloxirane

: 410077-37-1
(4S,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: CuI / tetrahydrofuran / 1 h / -40 °C

1.2: 83 percent / tetrahydrofuran / -45 - 0 °C

2.1: NaHMDS / tetrahydrofuran / 0.5 h / 0 °C

2.2: 99 percent / tetrahydrofuran / 1 h / 20 °C

3.1: IBr / diethyl ether; CH₂Cl₂ / 3.5 h / -100 - -78 °C

With copper(l) iodide; sodium hexamethyldisilazane; iodine(I) bromide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol017273z

Reference yield:

: 410077-69-9
1-(tert-butyl-diphenyl-silanyloxy)-2-methyl-pent-4-en-2-ol

: 410077-37-1
(4S,6R)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-6-iodomethyl-4-methyl-[1,3]dioxan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaHMDS / tetrahydrofuran / 0.5 h / 0 °C

1.2: 99 percent / tetrahydrofuran / 1 h / 20 °C

2.1: IBr / diethyl ether; CH₂Cl₂ / 3.5 h / -100 - -78 °C

With sodium hexamethyldisilazane; iodine(I) bromide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol017273z