5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide

Base Information

Chemical Name:5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide
CAS No.:948911-28-2
Molecular Formula:C₁₇H₁₉N₅O₃S
Molecular Weight:373.436
Hs Code.:

Synonyms:5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide

Suppliers and Price of 5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide

There total 7 articles about 5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 948911-24-8
5-amino-N-(benzyloxycarbonyl)-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide

: 948911-28-2
5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide

Guidance literature:: With sodium ethanolate; In ethanol; at 20 ℃; for 1h;
DOI:10.1007/s00706-006-0536-7

Reference yield:

: 948909-98-6
N-(4-methoxybenzyl)(cyanomethane)sulfonamide

: 948911-28-2
5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: BuLi / tetrahydrofuran / 0.17 h / -78 °C

1.2: 80 percent / tetrahydrofuran / 1 h / -78 °C

2.1: NaNO₂; conc. HCl / H₂O / 0 °C

2.2: 80 percent / NaOAc / H₂O / 0 - 20 °C

3.1: 85 percent / hydroxylamine hydrochloride; NaHCO₃ / H₂O; ethanol / 2 h / 50 °C

4.1: 80 percent / POCl₃ / 1 h / 0 °C

5.1: 60 percent / NaOEt / ethanol / 1 h / 20 °C

With hydrogenchloride; n-butyllithium; hydroxylamine hydrochloride; sodium ethanolate; sodium hydrogencarbonate; sodium nitrite; trichlorophosphate; In tetrahydrofuran; ethanol; water;
DOI:10.1007/s00706-006-0536-7

Reference yield:

: 948910-10-9
N-(benzyloxycarbonyl)-N-(4-methoxybenzyl)(cyanomethane)sulfonamide

: 948911-28-2
5-amino-N-(4-methoxybenzyl)-2-(4-methylphenyl)-2H-1,2,3-triazol-4-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaNO₂; conc. HCl / H₂O / 0 °C

1.2: 80 percent / NaOAc / H₂O / 0 - 20 °C

2.1: 85 percent / hydroxylamine hydrochloride; NaHCO₃ / H₂O; ethanol / 2 h / 50 °C

3.1: 80 percent / POCl₃ / 1 h / 0 °C

4.1: 60 percent / NaOEt / ethanol / 1 h / 20 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium ethanolate; sodium hydrogencarbonate; sodium nitrite; trichlorophosphate; In ethanol; water;
DOI:10.1007/s00706-006-0536-7