Technology Process of (S)-7,8a-dimethyl-6-phenyl-1,2,3,5,8,8a-hexahydroindolizine
There total 5 articles about (S)-7,8a-dimethyl-6-phenyl-1,2,3,5,8,8a-hexahydroindolizine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-tert-butyl 2-methyl-2-(2-oxopropyl)pyrrolidine-1-carboxylate;
With
trifluoroacetic acid;
In
dichloromethane;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
phenylacetaldehyde;
In
benzene;
at 20 ℃;
for 24h;
Inert atmosphere;
With
sodium tetrahydroborate;
In
methanol;
at 0 - 20 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/ol403229q
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; silver benzoate / 2 h / 45 °C / Inert atmosphere; Darkness
2.1: isopropylmagnesium chloride / tetrahydrofuran / 4.5 h / -20 - -8 °C / Inert atmosphere
3.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
4.2: 24 h / 20 °C / Inert atmosphere
4.3: 3 h / 0 - 20 °C / Inert atmosphere
With
isopropylmagnesium chloride; silver benzoate; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol403229q
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere
1.2: 4 h / 20 °C / Inert atmosphere
2.1: triethylamine; silver benzoate / 2 h / 45 °C / Inert atmosphere; Darkness
3.1: isopropylmagnesium chloride / tetrahydrofuran / 4.5 h / -20 - -8 °C / Inert atmosphere
4.1: tetrahydrofuran / 0 - 20 °C / Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
5.2: 24 h / 20 °C / Inert atmosphere
5.3: 3 h / 0 - 20 °C / Inert atmosphere
With
isopropylmagnesium chloride; silver benzoate; triethylamine; trifluoroacetic acid; isobutyl chloroformate;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol403229q
