N-(pyrrolidinylcarbonyl)-2-(methylsulfinyl)-4,5-dimethoxyaniline

Base Information

• Chemical Name: N-(pyrrolidinylcarbonyl)-2-(methylsulfinyl)-4,5-dimethoxyaniline
• CAS No.: 68559-73-9
• Molecular Formula: C₁₄H₂₀N₂O₄S
• Molecular Weight: 312.39
• Mol file: 68559-73-9.mol

Synonyms:N-(pyrrolidinylcarbonyl)-2-(methylsulfinyl)-4,5-dimethoxyaniline

Chemical Property of N-(pyrrolidinylcarbonyl)-2-(methylsulfinyl)-4,5-dimethoxyaniline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(pyrrolidinylcarbonyl)-2-(methylsulfinyl)-4,5-dimethoxyaniline

There total 5 articles about N-(pyrrolidinylcarbonyl)-2-(methylsulfinyl)-4,5-dimethoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(pyrrolidinylcarbonyl)-2-(methylthio)-4,5-dimethoxyaniline (68559-72-8) → N-(pyrrolidinylcarbonyl)-2-(methylsulfinyl)-4,5-dimethoxyaniline (68559-73-9)

Guidance literature:

With dihydrogen peroxide; In acetic acid; for 20h;

DOI:10.1021/jm00181a003

Reference yield:

2-(methylthio)-4,5-dimethoxyaniline (30058-46-9) → N-(pyrrolidinylcarbonyl)-2-(methylsulfinyl)-4,5-dimethoxyaniline (68559-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N-dimethylaniline / toluene / 4 h

2: acetonitrile / 20 h

3: 80 percent / H₂O₂ / acetic acid / 20 h

With dihydrogen peroxide; N,N-dimethyl-aniline; In acetic acid; toluene; acetonitrile;

DOI:10.1021/jm00181a003

Reference yield:

(4,5-dimethoxy-2-nitrophenyl)(methyl)sulfane (30058-45-8) → N-(pyrrolidinylcarbonyl)-2-(methylsulfinyl)-4,5-dimethoxyaniline (68559-73-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 62 percent / Sn, conc. HCl / acetic acid / 1.5 h / 100 - 105 °C

2: N,N-dimethylaniline / toluene / 4 h

3: acetonitrile / 20 h

4: 80 percent / H₂O₂ / acetic acid / 20 h

With hydrogenchloride; tin; dihydrogen peroxide; N,N-dimethyl-aniline; In acetic acid; toluene; acetonitrile;

DOI:10.1021/jm00181a003

upstream raw materials:

N-(pyrrolidinylcarbonyl)-2-(methylthio)-4,5-dimethoxyaniline

2-(methylthio)-4,5-dimethoxyaniline

1-bromo-4,5-dimethoxy-2-nitro-benzene

(4,5-dimethoxy-2-nitrophenyl)(methyl)sulfane

Downstream raw materials:

S-methyl-S-<2-<(pyrrolidinylcarbonyl)amino>-4,5-dimethoxyphenyl>sulfoximine