4-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-5-bromo-pyrimidine-2-carbonitrile

Base Information

Chemical Name:4-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-5-bromo-pyrimidine-2-carbonitrile
CAS No.:1392426-74-2
Molecular Formula:C₁₉H₁₉BrN₄O₂
Molecular Weight:415.289
Hs Code.:

Synonyms:4-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-5-bromo-pyrimidine-2-carbonitrile

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Chemical Property of 4-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-5-bromo-pyrimidine-2-carbonitrile

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Technology Process of 4-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-5-bromo-pyrimidine-2-carbonitrile

There total 4 articles about 4-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-5-bromo-pyrimidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: potassium cyanide

: 1392426-82-2
C₁₈H₁₉BrClN₃O₂

: 1392426-74-2
4-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-5-bromo-pyrimidine-2-carbonitrile

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In water; dimethyl sulfoxide; at 120 ℃; Inert atmosphere;
DOI:10.1039/c2ob00034b

Reference yield:

: 227017-79-0
N-(1,3-benzodioxol-5-ylmethyl)cyclohexanamine

: 1392426-74-2
4-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-5-bromo-pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 80 °C / Inert atmosphere

2: 1,4-diaza-bicyclo[2.2.2]octane / water; dimethyl sulfoxide / 120 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; N-ethyl-N,N-diisopropylamine; In water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1039/c2ob00034b

Reference yield:

: 2620-50-0
1,3-benzodioxol-5-ylmethyl amine

: 1392426-74-2
4-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-5-bromo-pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 1.5 h / 25 °C / Molecular sieve; Inert atmosphere

1.2: 25 h / 17 °C / Molecular sieve; Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 80 °C / Inert atmosphere

3.1: 1,4-diaza-bicyclo[2.2.2]octane / water; dimethyl sulfoxide / 120 °C / Inert atmosphere

With 1,4-diaza-bicyclo[2.2.2]octane; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; dimethyl sulfoxide; isopropyl alcohol;
DOI:10.1039/c2ob00034b