3H-[1,3]Dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-5,6-dihydro-

Base Information

Chemical Name:3H-[1,3]Dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-5,6-dihydro-
CAS No.:112970-23-7
Molecular Formula:C20H17 N O6
Molecular Weight:367.358
Hs Code.:
Mol file:112970-23-7.mol

Synonyms:3H-[1,3]Dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-5,6-dihydro-

Suppliers and Price of 3H-[1,3]Dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-5,6-dihydro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3H-[1,3]Dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-5,6-dihydro-

Chemical Property:

PSA：72.06000
LogP:3.07730

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3H-[1,3]Dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-5,6-dihydro-

There total 4 articles about 3H-[1,3]Dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one, 1-(3,4-dimethoxyphenyl)-5,6-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 112970-22-6
ethyl 1-(3,4-dimethoxybenzylidene)-3,4-dihydro-6,7-(methylenedioxy)-2(1H)-isoquinolinecarboxylate

: 112970-23-7
1-(3,4-dimethoxyphenyl)-5,6-dihydro-3H-[1,3]dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one

Guidance literature:: With lead(IV) acetate; In acetic acid;
DOI:10.1021/jo00241a011

Reference yield: 56.0%

: tert-butyl (2-(benzo[d][1,3]dioxol-5-yl)ethyl)((3,4-dimethoxyphenyl)ethynyl)carbamate

: 112970-23-7
1-(3,4-dimethoxyphenyl)-5,6-dihydro-3H-[1,3]dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one

Guidance literature:: tert-butyl (2-(benzo[d][1,3]dioxol-5-yl)ethyl)((3,4-dimethoxyphenyl)ethynyl)carbamate; With bis-[(trifluoroacetoxy)iodo]benzene; In dichloromethane; at 20 ℃; Molecular sieve; Inert atmosphere;

With boron trifluoride diethyl etherate; In methanol; dichloromethane; at -96 ℃; for 3h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.bmc.2017.03.034

Reference yield:

: 2221-44-5
5-(3,4-dimethoxy-benzyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline

: 112970-23-7
1-(3,4-dimethoxyphenyl)-5,6-dihydro-3H-[1,3]dioxolo[4,5-g]oxazolo[4,3-a]isoquinolin-3-one

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) I₂ / 1.) toluene, reflux, 2.) benzene, reflux, 2 h

2: 71 percent / lead tetraacetate / acetic acid

With lead(IV) acetate; iodine; In acetic acid;
DOI:10.1021/jo00241a011