3-(4-phenoxyphenyl)-1-(6-azaspiro[3.5]nonan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Base Information

Chemical Name:3-(4-phenoxyphenyl)-1-(6-azaspiro[3.5]nonan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.:1448850-41-6
Molecular Formula:C₂₅H₂₆N₆O
Molecular Weight:426.521
Hs Code.:

Synonyms:3-(4-phenoxyphenyl)-1-(6-azaspiro[3.5]nonan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Chemical Property of 3-(4-phenoxyphenyl)-1-(6-azaspiro[3.5]nonan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Technology Process of 3-(4-phenoxyphenyl)-1-(6-azaspiro[3.5]nonan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

There total 4 articles about 3-(4-phenoxyphenyl)-1-(6-azaspiro[3.5]nonan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1448850-40-5
benzyl 2-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-6-azaspiro[3.5]nonane-6-carboxylate

: 1448850-41-6
3-(4-phenoxyphenyl)-1-(6-azaspiro[3.5]nonan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: With 10 wt% Pd(OH)2 on carbon; hydrogen; acetic acid; In tetrahydrofuran; methanol; at 20 ℃; for 48h;

Reference yield:

: 151266-23-8
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine

: 1448850-41-6
3-(4-phenoxyphenyl)-1-(6-azaspiro[3.5]nonan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / tetrahydrofuran; water / 110 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3: 10 wt% Pd(OH)2 on carbon; hydrogen; acetic acid / tetrahydrofuran; methanol / 48 h / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; di-isopropyl azodicarboxylate; 10 wt% Pd(OH)2 on carbon; hydrogen; sodium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; water; 1: |Suzuki Coupling / 2: |Mitsunobu Displacement;

Reference yield:

: 330786-24-8
3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

: 1448850-41-6
3-(4-phenoxyphenyl)-1-(6-azaspiro[3.5]nonan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: 10 wt% Pd(OH)2 on carbon; hydrogen; acetic acid / tetrahydrofuran; methanol / 48 h / 20 °C

With di-isopropyl azodicarboxylate; 10 wt% Pd(OH)2 on carbon; hydrogen; acetic acid; triphenylphosphine; In tetrahydrofuran; methanol; 1: |Mitsunobu Displacement;