Technology Process of (E)-(2R,4S,5R)-1-Benzyloxy-5-hydroxy-2,4-dimethyl-oct-6-en-3-one
There total 7 articles about (E)-(2R,4S,5R)-1-Benzyloxy-5-hydroxy-2,4-dimethyl-oct-6-en-3-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-1-(benzyloxy)-2-methylpentan-3-one;
With
tin(II) trifluoromethanesulfonate; triethylamine;
In
dichloromethane;
at -78 ℃;
for 2h;
trans-Crotonaldehyde;
In
dichloromethane;
at -78 - 20 ℃;
DOI:10.1016/j.tet.2006.06.046
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 81 percent / TfOH / CH2Cl2; cyclohexane / 16 h / Ambient temperature
2: 1.) Me3Al / 1.) toluene, from 0 deg C to RT, 15 min, 2.) toluene, from 70 to 80 deg C, 2 h
3: tetrahydrofuran / 1 h / 0 °C
4: 1.) (cyclohexyl)2BCl, Et3N, 3.) 30percent aq. H2O2, pH 7 buffer
With
trifluorormethanesulfonic acid; pH 7 buffer; dicyclohexylboron chloride; dihydrogen peroxide; trimethylaluminum; triethylamine;
In
tetrahydrofuran; dichloromethane; cyclohexane;
DOI:10.1021/ja00104a010
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) Me3Al / 1.) toluene, from 0 deg C to RT, 15 min, 2.) toluene, from 70 to 80 deg C, 2 h
2: tetrahydrofuran / 1 h / 0 °C
3: 1.) (cyclohexyl)2BCl, Et3N, 3.) 30percent aq. H2O2, pH 7 buffer
With
pH 7 buffer; dicyclohexylboron chloride; dihydrogen peroxide; trimethylaluminum; triethylamine;
In
tetrahydrofuran;
DOI:10.1021/ja00104a010
