3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Base Information

• Chemical Name: 3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide
• CAS No.: 1442452-29-0
• Molecular Formula: C₂₂H₂₃BrN₄O₄
• Molecular Weight: 487.353
• Mol file: 1442452-29-0.mol

Synonyms:3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Chemical Property of 3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide

There total 5 articles about 3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid methyl ester (1442452-28-9) + N,N-dimethylhydroxylamine hydrochloride (16645-06-0) → 3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide (1442452-29-0)

Guidance literature:

3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid methyl ester; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 3h;

With 1,1'-carbonyldiimidazole; at 20 ℃; for 1h;

N,N-dimethylhydroxylamine hydrochloride; With triethylamine; for 18h;

Reference yield:

4-methyl-3-[2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-benzoic acid methyl ester (1442452-27-8) → 3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide (1442452-29-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 3 h / 20 °C

2.2: 1 h / 20 °C

2.3: 18 h

With N-Bromosuccinimide; sodium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

3-(4-hydroxy-2-methyl-6-oxo-6H-pyrimidin-1-yl)-4-methyl-benzoic acid methyl ester (1442451-93-5) → 3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-N-methoxy-4,N-dimethyl-benzamide (1442452-29-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate; 18-crown-6 ether / N,N-dimethyl-formamide

2.1: N-Bromosuccinimide / dichloromethane / 2 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran / 3 h / 20 °C

3.2: 1 h / 20 °C

3.3: 18 h

With N-Bromosuccinimide; 18-crown-6 ether; potassium carbonate; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

4-methyl-3-[2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-benzoic acid methyl ester

3-(4-hydroxy-2-methyl-6-oxo-6H-pyrimidin-1-yl)-4-methyl-benzoic acid methyl ester

3-[5-bromo-2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-4-methyl-benzoic acid methyl ester

N,N-dimethylhydroxylamine hydrochloride

Downstream raw materials:

5-bromo-3-(5-(2-(2-hydroxypropan-2-yl)pyrimidin-4-yl)-2-methylphenyl)-2-methyl-6-((6-methylpyridin-2-yl)methoxy)pyrimidin-4(3H)-one

5-bromo-2-methyl-3-(2-methyl-5-propynoyl-phenyl)-6-(6-methyl-pyridin-2-ylmethoxy)-3H-pyrimidin-4-one