1,6,7,8-tetrahydro-3,6,6-trimethyl-2-benzoxepine

Base Information

• Chemical Name: 1,6,7,8-tetrahydro-3,6,6-trimethyl-2-benzoxepine
• CAS No.: 909697-71-8
• Molecular Formula: C₁₃H₁₈O
• Molecular Weight: 190.285
• Mol file: 909697-71-8.mol

Synonyms:1,6,7,8-tetrahydro-3,6,6-trimethyl-2-benzoxepine

Chemical Property of 1,6,7,8-tetrahydro-3,6,6-trimethyl-2-benzoxepine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1,6,7,8-tetrahydro-3,6,6-trimethyl-2-benzoxepine

There total 3 articles about 1,6,7,8-tetrahydro-3,6,6-trimethyl-2-benzoxepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

Acetic acid (1R,3S)-4,4-dimethyl-2-methylene-3-((E)-3-oxo-but-1-enyl)-cyclohexyl ester → (3E)-4-(2,2-dimethyl-6-methylenecyclohex-4-en-1-yl)but-3-en-2-one (67233-98-1) + 1,6,7,8-tetrahydro-3,6,6-trimethyl-2-benzoxepine (909697-71-8)

Guidance literature:

With palladium diacetate; triphenylphosphine; calcium carbonate; In 1,4-dioxane; for 4h; Heating;

DOI:10.1002/hlca.200690109

Reference yield: 77.0%

(+)-(4R,6S)-4-(acetyloxy)-γ-ionone (909697-73-0) → 1,6,7,8-tetrahydro-3,6,6-trimethyl-2-benzoxepine (909697-71-8) + (+)-(6S)-3,4-didehydro-γ-ionone (909697-75-2)

Guidance literature:

With palladium diacetate; triphenylphosphine; calcium carbonate; In 1,4-dioxane; for 4h; Heating;

DOI:10.1002/hlca.200690109

Reference yield: 71.0%

(3E)-4-{cis-5-[(4-nitrobenzoyl)oxy]-2,2-dimethyl-6-methylenecyclohexyl}but-3-en-2-one → (3E)-4-(2,2-dimethyl-6-methylenecyclohex-4-en-1-yl)but-3-en-2-one (67233-98-1) + 1,6,7,8-tetrahydro-3,6,6-trimethyl-2-benzoxepine (909697-71-8)

Guidance literature:

With palladium diacetate; triphenylphosphine; calcium carbonate; In 1,4-dioxane; for 4h; Heating;

DOI:10.1002/hlca.200690109

upstream raw materials:

(+)-(4R,6S)-4-(acetyloxy)-γ-ionone

Downstream raw materials:

4-(2,2,6-trimethylcyclohexyl)-butan-2-one