(R)-5-azido-4,4-difluoro-3-benzyloxy-pent-1-ene

Base Information

Chemical Name:(R)-5-azido-4,4-difluoro-3-benzyloxy-pent-1-ene
CAS No.:1215861-28-1
Molecular Formula:C₁₂H₁₃F₂N₃O
Molecular Weight:253.252
Hs Code.:

Synonyms:(R)-5-azido-4,4-difluoro-3-benzyloxy-pent-1-ene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-azido-4,4-difluoro-3-benzyloxy-pent-1-ene

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Technology Process of (R)-5-azido-4,4-difluoro-3-benzyloxy-pent-1-ene

There total 5 articles about (R)-5-azido-4,4-difluoro-3-benzyloxy-pent-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₃N₃O₂

: 1215861-28-1
(R)-5-azido-4,4-difluoro-3-benzyloxy-pent-1-ene

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; at -25 - 20 ℃;

Reference yield:

: 922-65-6
divinylcarbinol

: 1215861-28-1
(R)-5-azido-4,4-difluoro-3-benzyloxy-pent-1-ene

Guidance literature:: Multi-step reaction with 5 steps

1.1: Cumene hydroperoxide / titanium(IV) isopropylate; L-(+)-diisopropyl tartrate / dichloromethane / 48 h / -35 °C / Molecular sieve

2.1: sodium hydride / tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / -15 - 20 °C / Inert atmosphere

3.1: sodium azide; ammonium chloride / water; methanol / 96 h

4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

4.2: 2 h / -15 °C

5.1: diethylamino-sulfur trifluoride / dichloromethane / 48 h / -25 - 20 °C

With sodium azide; oxalyl dichloride; diethylamino-sulfur trifluoride; Cumene hydroperoxide; sodium hydride; ammonium chloride; dimethyl sulfoxide; titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil; 4.1: Swern Oxidation / 4.2: Swern Oxidation;

Reference yield:

: 102490-00-6
(2S,3R)-1,2-epoxy-4-penten-3-ol

: 1215861-28-1
(R)-5-azido-4,4-difluoro-3-benzyloxy-pent-1-ene

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / -15 - 20 °C / Inert atmosphere

2.1: sodium azide; ammonium chloride / water; methanol / 96 h

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

3.2: 2 h / -15 °C

4.1: diethylamino-sulfur trifluoride / dichloromethane / 48 h / -25 - 20 °C

With sodium azide; oxalyl dichloride; diethylamino-sulfur trifluoride; sodium hydride; ammonium chloride; dimethyl sulfoxide; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil; 3.1: Swern Oxidation / 3.2: Swern Oxidation;