2,3,3-trimethyl-4-phenylbutanoyl chloride

Base Information

• Chemical Name: 2,3,3-trimethyl-4-phenylbutanoyl chloride
• CAS No.: 167212-35-3
• Molecular Formula: C₁₃H₁₇ClO
• Molecular Weight: 224.73
• Mol file: 167212-35-3.mol

Synonyms:2,3,3-trimethyl-4-phenylbutanoyl chloride

Chemical Property of 2,3,3-trimethyl-4-phenylbutanoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,3-trimethyl-4-phenylbutanoyl chloride

There total 4 articles about 2,3,3-trimethyl-4-phenylbutanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,3-trimethyl-4-phenylbutanoic acid (80607-57-4) → 2,3,3-trimethyl-4-phenylbutanoyl chloride (167212-35-3)

Guidance literature:

With thionyl chloride; at 5 ℃; for 24h;

DOI:10.1016/S0040-4020(01)91479-6

Reference yield:

2-cyano-3,3-dimethyl-4-phenyl-butyric acid ethyl ester (6333-05-7) → 2,3,3-trimethyl-4-phenylbutanoyl chloride (167212-35-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / NaOEt / ethanol / 12 h / Heating

2: 70 percent / NaOH / ethane-1,2-diol / 36 h / 150 °C

3: 71 percent / N₂O₄ / acetic acid / 3 h / 10 °C

4: thionyl chloride / 24 h / 5 °C

With sodium hydroxide; thionyl chloride; sodium ethanolate; dinitrogen tetraoxide; In ethanol; ethylene glycol; acetic acid;

Reference yield:

2,3,3-Trimethyl-4-phenylbutyramid (80607-84-7) → 2,3,3-trimethyl-4-phenylbutanoyl chloride (167212-35-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / N₂O₄ / acetic acid / 3 h / 10 °C

2: thionyl chloride / 24 h / 5 °C

With thionyl chloride; dinitrogen tetraoxide; In acetic acid;

upstream raw materials:

2,3,3-trimethyl-4-phenylbutanoic acid

2-cyano-3,3-dimethyl-4-phenyl-butyric acid ethyl ester

2,3,3-Trimethyl-4-phenylbutyramid

2-Cyan-2,3,3-trimethyl-4-phenylbuttersaeure-ethylester

Downstream raw materials:

(1,1-dimethyl-2-phenylethyl)methylketen-N-(2,6-dichlorophenyl)-imine

(1,1-dimethyl-2-phenylethyl)methylketen-N-(2-tert-butylphenyl)-imine

(1,1-dimethyl-2-phenylethyl)methylketen-N-(2-chloro-6-methylphenyl)-imine

(1,1-dimethyl-2-phenylethyl)methylketen-N-(2-isopropylphenyl)-imine