1-[2-fluoro-4-[2-(4-fluorophenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol

Base Information

Chemical Name:1-[2-fluoro-4-[2-(4-fluorophenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol
CAS No.:81228-31-1
Molecular Formula:C₂₂H₂₉F₂NO₄
Molecular Weight:409.473
Hs Code.:

Synonyms:1-[2-fluoro-4-[2-(4-fluorophenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol

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Chemical Property of 1-[2-fluoro-4-[2-(4-fluorophenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol

Chemical Property:

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Technology Process of 1-[2-fluoro-4-[2-(4-fluorophenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol

There total 10 articles about 1-[2-fluoro-4-[2-(4-fluorophenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7589-27-7
2-(4-Fluorophenyl)ethanol

: 81228-31-1
1-[2-fluoro-4-[2-(4-fluorophenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, 60 deg C, 10 min, 2.) DMF, 60 deg C, 30 min

2: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

3: pyridine / 0.5 h

4: 74 percent / NaH / dimethylformamide / 0.75 h / 60 °C

5: 87 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate

6: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

7: ethanol / 18 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00365a005

Reference yield:

: 81228-11-7
4-Fluoro-1-[2-[2-hydroxyethoxy]ethyl]benzene

: 81228-31-1
1-[2-fluoro-4-[2-(4-fluorophenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 0.5 h

2: 74 percent / NaH / dimethylformamide / 0.75 h / 60 °C

3: 87 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate

4: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

5: ethanol / 18 h / Ambient temperature

With pyridine; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00365a005

Reference yield:

: 81228-04-8
<<2-(4-fluorophenyl)ethyl>oxy>acetic acid

: 81228-31-1
1-[2-fluoro-4-[2-(4-fluorophenethyloxy)ethoxy]phenoxy]-3-isopropylamino-2-propanol

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / Ambient temperature

2: pyridine / 0.5 h

3: 74 percent / NaH / dimethylformamide / 0.75 h / 60 °C

4: 87 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate

5: 1.) NaH / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min

6: ethanol / 18 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00365a005