methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

Base Information

Chemical Name:methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate
CAS No.:1632322-89-4
Molecular Formula:C₂₂H₂₈N₂O₃
Molecular Weight:368.476
Hs Code.:

Synonyms:methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

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Chemical Property of methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

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Technology Process of methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

There total 5 articles about methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 517-22-6
2,4-dimethyl-3-ethyl-pyrrole

: 1632322-82-7
methyl (S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate

: 1632322-90-7
(S)-methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

: 1632322-89-4
methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

Guidance literature:: 2,4-dimethyl-3-ethyl-pyrrole; With aluminum (III) chloride; In dichloromethane; at 25 ℃; Inert atmosphere;

methyl (S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate; In dichloromethane; at 25 ℃; Overall yield = 85 %; Overall yield = 135 mg; Optical yield = 63.636 %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1341275

Reference yield:

: 1632322-82-7
methyl (S)-2-(2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate

: 1632324-67-4
C₈H₁₃AlCl₃N

: 1632322-90-7
(S)-methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

: 1632322-89-4
methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

Guidance literature:: In dichloromethane; at 25 ℃; Optical yield = 63.636 %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1341275

Reference yield:

: 1632323-19-3
C₁₆H₁₉NO₃

: 1632322-90-7
(S)-methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

: 1632322-89-4
methyl 2-(4-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-oxopyrrolidin-1-yl)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: allyl-trimethyl-silane; Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 25 °C / Inert atmosphere

2.1: aluminum (III) chloride / dichloromethane / 25 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

With aluminum (III) chloride; Hoveyda-Grubbs catalyst second generation; allyl-trimethyl-silane; In dichloromethane; 2.1: |Friedel-Crafts Alkylation / 2.2: |Friedel-Crafts Alkylation;
DOI:10.1055/s-0033-1341275