3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine

Base Information

• Chemical Name: 3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine
• CAS No.: 199931-18-5
• Molecular Formula: C₄₁H₄₂N₂O₉
• Molecular Weight: 706.792
• Mol file: 199931-18-5.mol

Synonyms:3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine

Chemical Property of 3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine

There total 14 articles about 3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 3'-C-(3-benzoyloxypropyl)thymidine (199931-13-0) → 3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine (199931-18-5)

Guidance literature:

With pyridine; Ambient temperature;

Reference yield:

Benzoic acid 3-[(2R,3S,5R)-3-benzyloxy-2-benzyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-propyl ester (199931-15-2) → 3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine (199931-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / H₂ / Pd(OH)2/C / ethanol / Ambient temperature

2: 90 percent / pyridine / Ambient temperature

With pyridine; hydrogen; palladium dihydroxide; In ethanol;

Reference yield:

Benzoic acid 3-[(2R,3R,4R,5R)-3-benzyloxy-2-benzyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-pentafluorophenyloxythiocarbonyloxy-tetrahydro-furan-3-yl]-propyl ester (199931-16-3) → 3'-C-(3-benzoyloxypropyl)-5'-O-(4,4'-dimethoxytrityl)thymidine (199931-18-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 52 percent / AIBN, Bu₃SnH / benzene / 1 h / Heating

2: 65 percent / H₂ / Pd(OH)2/C / ethanol / Ambient temperature

3: 90 percent / pyridine / Ambient temperature

With pyridine; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; palladium dihydroxide; In ethanol; benzene;

upstream raw materials:

4,4'-dimethoxytrityl chloride

3'-C-(3-benzoyloxypropyl)thymidine

benzoyl chloride

Benzoic acid 3-[(2R,3S,5R)-3-benzyloxy-2-benzyloxymethyl-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl]-propyl ester