(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(pyridin-2-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Base Information

Chemical Name:(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(pyridin-2-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline
CAS No.:1438285-47-2
Molecular Formula:C₂₈H₃₁N₃
Molecular Weight:409.574
Hs Code.:

Synonyms:(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(pyridin-2-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

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Chemical Property of (4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(pyridin-2-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

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Technology Process of (4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(pyridin-2-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

There total 12 articles about (4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(pyridin-2-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1438285-46-1
C₃₁H₃₉N₃Si

: 1438285-47-2
(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(pyridin-2-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Guidance literature:: With tetrabutyl ammonium fluoride; In 1,4-dioxane; at 23 ℃; Inert atmosphere; Heating;
DOI:10.1021/jo400695c

Reference yield:

: 1225377-69-4
2-((1S,2R,3R,5R)-3-ethynyl-2-(3-hydroxypropyl)-3-(benzylamino)-5-methylcyclohexyl)acetonitrile

: 1438285-47-2
(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(pyridin-2-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; 1H-imidazole / tetrachloromethane / 15 h / 77 °C / Inert atmosphere

2: dicarbonylcyclopentadienylcobalt / tetrahydrofuran / 140 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / 1,4-dioxane / 23 °C / Inert atmosphere; Heating

With 1H-imidazole; dicarbonylcyclopentadienylcobalt; tetrabutyl ammonium fluoride; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane;
DOI:10.1021/jo400695c

Reference yield:

: 1225377-71-8
2-((4aR,5R,7S,8aS)-1-benzyl-8a-ethynyl-7-methyldecahydroquinolin-5-yl)acetonitrile

: 1438285-47-2
(4aR,5S,10bR,12R)-1-benzyl-12-methyl-8-(pyridin-2-yl)-2,3,4,4a,5,6-hexahydro-1H-5,10b-propano-1,7-phenanthroline

Guidance literature:: Multi-step reaction with 2 steps

1: dicarbonylcyclopentadienylcobalt / tetrahydrofuran / 140 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / 1,4-dioxane / 23 °C / Inert atmosphere; Heating

With dicarbonylcyclopentadienylcobalt; tetrabutyl ammonium fluoride; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jo400695c